81935-64-0Relevant academic research and scientific papers
A novel process for antimalarial drug pyronaridine tetraphosphate
Liu, Yu,Zhang, Zixue,Wu, Anfei,Yang, Xiaoli,Zhu, Yong,Zhao, Nan
, p. 349 - 353 (2014)
A novel process for preparation of pyronaridine tetraphosphate, an antimalarial drug substance, is reported. The overall yields are 54% and >99.8% (including five chemical steps). Formation and control of possible impurities are also described.
Improved manufacturing process for pyronaridine tetraphosphate
Lee, Dong Won,Lee, Seung Kyu,Cho, Jun Ho,Yoon, Seung Soo
, p. 521 - 524 (2014/03/21)
Pyronaridine tetraphosphate (1) is a well-known antimalarial drug. However, it required a carefully optimized production process for the manufacture of pyronaridine tetraphosphate. Each step of its manufacturing process was reinvestigated. For the cyclization of 4-chloro-2-(6-methoxy-pyridin-3-yl-amino) -benzoic acid 6 to 7,10- dichloro-2-methoxybenzo[b]-1,5-naphthyridine 5, an improved process was developed to eliminated critical process impurity (BIA). By the redesign of the formation of triphosphate salt, the purity as API grade was increased. Thus, a robust manufacturing process with an acceptable process performance has been developed to produce high quality pyronaridine tetraphosphate.
