Organic Process Research and Development p. 349 - 353 (2014)
Update date:2022-09-26
Topics:
Liu, Yu
Zhang, Zixue
Wu, Anfei
Yang, Xiaoli
Zhu, Yong
Zhao, Nan
A novel process for preparation of pyronaridine tetraphosphate, an antimalarial drug substance, is reported. The overall yields are 54% and >99.8% (including five chemical steps). Formation and control of possible impurities are also described.
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