81935-68-4Relevant academic research and scientific papers
Highly sensitive and selective “naked eye” sensing of Cu(II) by a novel acridine-based sensor both in aqueous solution and on the test kit
Dai, Qiuzi,Gao, Chunmei,Liu, Yijia,Liu, Haiyang,Xiao, Boren,Chen, Chengken,Chen, Jiwei,Yuan, Zigao,Jiang, Yuyang
supporting information, p. 6459 - 6464 (2018/10/02)
A highly selective and sensitive acridine-based colorimetric sensor 2-((7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino)phenol (NAP) was developed for detection of Cu2+ ions both in aqueous solution and on test papers. Sensor NAP responses to Cu2+ ions by changing its color from yellow to pink, which could be easily observed by the naked eyes. Furthermore, the mechanism of the binding model of NAP-Cu2+ complex was investigated by 1H NMR, HRMS analysis, and DFT calculations.
Novel synthetic azaacridine analogues as topoisomerase 1 inhibitors
Luan, Xudong,Gao, Chunmei,Sun, Qinsheng,Tan, Chunyan,Liu, Hongxia,Jin, Yibao,Jiang, Yuyang
, p. 728 - 729 (2011/08/06)
Novel azaacridine analogues were synthesized and their antiproliferative activities against K562 and HepG-2 cell lines were evaluated, among which compound 5a was found to display good cytotoxicity. UVvisible spectral absorbance measurements showed that 5a can bind with calf thymus DNA (ct DNA). A relaxation assay indicated that 5a inhibits topoisomerase 1 activity.
