81937-39-5

Usage

Uses

Used in Medicinal Chemistry:
Diethyl 2-(1-(4-acetamidophenyl)-1-oxopropan-2-yl)malonate is used as a potential compound in medicinal chemistry for its unique structural components, which may contribute to the development of new pharmaceutical agents.
Used in Polymer Science:
In polymer science, diethyl 2-(1-(4-acetamidophenyl)-1-oxopropan-2-yl)malonate is utilized as a component in the synthesis of novel polymers, potentially offering new properties and applications in material science.
Used in Pharmaceutical Research:
Diethyl 2-(1-(4-acetamidophenyl)-1-oxopropan-2-yl)malonate is employed in pharmaceutical research as a candidate for drug development, given its complex structure that may possess bioactivity or serve as a building block for more complex molecules.
Note: The specific applications and reasons for using diethyl 2-(1-(4-acetamidophenyl)-1-oxopropan-2-yl)malonate are inferred based on its structural components and potential relevance in fields where complex organic compounds are utilized. Due to the limited information available, these uses are speculative and may require further research and validation.

Upstream product

• 81112-08-5 N-[4-(2-chloro-1-oxopropyl)phenyl]acetamide 
• 105-53-3 diethyl malonate 
• 63514-63-6 N-(4-(2-bromopropionyl)phenyl)acetamide 
• 103-84-4 Acetanilid 
• 16960-49-9 N-(4-propionylphenyl)acetamide 

Downstream Products

• 1221499-55-3 C₁₈H₁₆N₄O₃ 
• 1221499-56-4 C₁₈H₁₆N₄O₃ 
• 1221499-57-5 C₁₈H₁₇N₃O₃ 
• 1221499-58-6 C₁₈H₁₇N₃O₂ 
• 1221499-59-7 C₁₈H₁₇N₃O₂ 
• 1221499-60-0 C₁₈H₁₆ClN₃O 
• 1221499-61-1 C₂₁H₂₃N₃O₄ 
• 1221499-62-2 C₁₈H₁₅Cl₂N₃O 
• 1221499-63-3 (R)-(-)-6-[4-(2-pyridinylmethylene)amino]phenyl-5-methyl-4,5-dihydro-3(2H)-pyridazinone 
• 1221499-65-5 (R)-(-)-6-[4-(2-furanylmethylene)amino]phenyl-5-methyl-4,5-dihydro-3(2H)-pyridazinone 
• 36725-28-7 OR-1855 
• 136609-85-3 6-(3,4-diaminophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one 
• 36725-28-7 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone 
• 115344-47-3 2 cyano 1 methyl 3 [4 (4 methyl 6 oxo 1,4,5,6 tetrahydro 3 pyridazinyl)phenyl]guanidine 

Relevant academic research and scientific papers

Preparation method of key intermediate of Pimobendan

The invention discloses a preparation method of a key intermediate of Pimobendan. The method comprises steps as follows: (i) a compound I is synthesized; (ii) the compound I is subjected to nucleophilic substitution, and a compound II is produced; (iii) t

Synthesis and anti-congestive heart failure activity of novel levosimendan analogues

A series of levosimendan analogues were designed and synthesized, employing the Friedel-Crafts reaction, hydrolysis, and cyclization from the key intermediate compound R(-)-6-(4-aminophenyl)-5-methyl-4, 5-dihydro-3(2H)- pyridazinone, which was obtained from the starting material, acetanilide. These compounds, except 1b, exhibited potent anti-congestive heart failure activities, especially the compounds 1e and 1k, which showed more effective action than levosimendan. Springer Science+Business Media, LLC 2010.

Synthesis and bioactivity of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives

A series of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives was prepared and examined for cardiotonic activity. The structures of these new pyridazinone derivatives were confirmed by IR, 1H-NMR and mass spectrum. The cardiotonic activities of these compounds were studied on isolated perfused toad heart and compared with the activity of levosimendan (CAS 141505-33-1). Compound 5a emerged as the most interesting compound in this series with potential cardiotonic activity. ECV Editio Cantor Verlag.

Arylalkane, arylalkene and aryl azaalkane, medicaments containing said compounds and method for the production thereof

The present invention relates to compounds of general formula [in-line-formulae]R—Z1—Z2—Z3—R1, ??(I)[/in-line-formulae] wherein R, R1 and Z1 to Z3 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

6-(substituted phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-ones of medicinal interest. The synthesis of SK&F 94836 and SK&F 95654

Two synthetic routes to the dihydropyridazinone-cyanoguanidine 4 (SK&F 94836) are described, both proceeding via the anilino compound 6. An efficient synthesis of the dihydropyridazinone-pyridone 5 (SK&F 95654) is reported. This synthesis proceeds via the fluoro-keto-acid 24, with subsequent displacement of the fluoro substituent by 4-pyridone. The surprising effectiveness of water as a solvent in this reaction has been highlighted.