81946-79-4

Upstream product

• 81946-78-3 4-[3-(p-nitrobenzyloxycarbonyl)-2-oxopropyl]-azetidin-2-one 
• 28562-53-0 4-acetoxy azetidinone 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 82551-63-1 4-nitrobenzyl 2-diazo-3-oxo-butanoate 
• 77960-43-1 2-(4-oxoazetidin-2-yl)acetic acid 
• 94271-74-6 4-[1-(2,4-Dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester 
• 91921-97-0 (4RS)-4-diazoacetyl-1-(2,4-dimethoxybenzyl)azetidin-2-one 
• 91921-98-1 [1-(2,4-dimethoxy-benzyl)-4-oxo-2-azetidinyl]-acetic acid 
• 94271-60-0 (4-Oxo-azetidin-2-yl)-acetic acid benzhydryl ester 
• 87785-68-0 p-nitrobenzyl 4-(N-chlorosulfonyl-2-azetidinon-4-yl)-3-butenoate 
• 87785-69-1 p-nitrobenzyl 4-(2-azetidinon-4-yl)-3-butenoate 
• 87785-70-4 p-nitrobenzyl 4-(2-azetidinon-4-yl)-2-butenoate 
• 87785-65-7 p-nitrobenzyl 3,5-hexadienoate 
• 32775-95-4 (E)-3,5-hexadienoic acid 

Downstream Products

• 87785-73-7 potassium 2-benzylthiocarbapen-2-em-3-carboxylate 
• 75440-14-1 p-nitrobenzyl 2-benzylthiocarbapen-2-em-3-carboxylate 
• 101989-36-0 3-(Diphenoxy-phosphoryloxy)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 81946-80-7 p-nitrobenzyl 2-oxocarbapenam-3-carboxylate 
• 81946-80-7 p-nitrobenzyl (3RS,5RS)-2-oxocarbapenam-3-carboxylate 

Relevant academic research and scientific papers

6- and 6,6-disubstituted-3-substituted-1-azabicyclo(3.2.0)hept-2-en-7-one-2-carboxylic acids

Disclosed are 6- and 6,6-disubstituted-3-substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acids (I): STR1 wherein R1 and R2 are, inter alia, independently selected from the group consisting of hydrogen (both are not hydrog

Process for preparing 3-substituted-6-substituted-7-oxo-1-azabicycl(3.2.0)-hept-2-ene-2-carboxylic acid

Disclosed is a process for preparing 3-substituted-thio-6-(1'-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acids (I) STR1 wherein X is a leaving group such as chloro, bromo, tosyl, mesyl or the like; and R8 is, inter alia, sel

Process for the preparation of carbapenem intermediates

A process for the preparation of a 4-[3-carboxy-3-diazo-2-oxopropyl]azetidin-2-one of the formula STR1 comprising reacting a 4-acetoxy-2-azetininone of the formula STR2 with a compound of the formula STR3 in an inert solvent, in the presence of a base and of a silylating agent, in a one-pot process. Many of the products are new. The products are useful in the synthesis of carbapenem antibiotics.

Process for preparing 3-substituted-6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Disclosed is a process for preparing 3- and 6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acids: STR1 wherein: X is a leaving group such as chloro, bromo, tosyl, mesyl or the like; and R6, R7 and R8 are, i

Simple and Condensed β-Lactams. Part 5. The Synthesis of some (5RS,6SR)-2-(Formylaminoethylthio)-6-(2-methyl-1,3-dioxolan-2-yl)carbapenem-3-carboxylic Acid Derivatives and Related Compounds

Starting with the 4-oxoazetidine-2-carboxylic acids (3a) and (3b), methods for the synthesis of derivatives of the racemic carbapenem-3-carboxylic acid (2), an analogue of the potent antibiotic thienamycin have been developed.The synthetic steps included

6- And 6,6-disubstituted-3-substituted amino-1-azabicyclo-[3.2.0]hept-2-en-7-one-2-carboxylic acid

Disclosed are 6- and 6,6-disubstituted-3-substituted amino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acids (I): STR1 wherein R1 and R2 are, inter alia, independently selected from the group consisting of hydrogen, substituted a

6-(1'-Hydroxyethyl)-3-substituted amino-1-azabicyclo-?3.2.0!hept-2-en-7-one-2-carboxylic acid

Disclosed are 6-(1'-hydroxyethyl)-3-substituted amino-1-azabicyclo?3.2.0!hept-2-en-7-one-2-carboxylic acids (I): STR1 wherein R' and R" are independently selected from H, substituted and unsubstituted alkyl and aralkyl groups, or together form a substitut

3-Substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid

Disclosed are 3-substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acids (I): STR1 wherein R is, inter alia, acyl, alkyl, and aralkyl. Such compounds and their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotic

1-Azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid

Disclosed are the pharmaceutically acceptable salt and ester forms of 1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid (I): STR1 Such compounds are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceuti