81962-58-5

Basic information

• Product Name: N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)ACETAMIDE
• Synonyms: 5'-CHLORO-4'-FLUORO-2'-NITROACETANILIDE;5-CHLORO-4-FLUORO-2-NITROACETANILIDE;N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)ACETAMIDE;5''-CHLORO-4''-FLURO-2''-NITROACETANILIDE
• CAS NO: 81962-58-5
• Molecular Formula: C₈H₆ClFN₂O₃
• Molecular Weight: 232.6
• Mol File: 81962-58-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 109-112°C
• Appearance: /
• CAS DataBase Reference: N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)ACETAMIDE(81962-58-5)
• EPA Substance Registry System: N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)ACETAMIDE(81962-58-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 81962-58-5(Hazardous Substances Data)

Usage

General Description

N1-(5-chloro-4-fluoro-2-nitrophenyl)acetamide is a chemical compound with the molecular formula C8H7ClFNO3. It is an organic amide with a nitro-substituted phenyl ring and a chloro-fluoro substitution on the aromatic ring. It has the potential to be used in the pharmaceutical industry as an intermediate or building block in the synthesis of various drugs. This chemical may also have potential applications in research and development, particularly in the design and synthesis of new pharmaceutical compounds. Additionally, it may have uses in the development of agrochemicals and other specialty chemicals. As with any chemical substance, proper handling and safety precautions should be observed when working with N1-(5-chloro-4-fluoro-2-nitrophenyl)acetamide to prevent any potential hazards.

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 108-24-7 acetic anhydride 
• 877-90-7 N-(3-chloro-4-fluorophenyl)acetamide 

Downstream Products

• 104222-34-6 2-nitro-4-fluoro-5-chloroaniline 
• 81962-60-9 2-nitro-4-fluoro-5-(4-hydroxy-1-piperidyl)acetanilide 
• 218456-76-9 6-chloro-7-fluoro-2, 3-diphenylquinoxaline 
• 139512-70-2 4-chloro-5-fluorobenzene-1,2-diamine 
• 473547-10-3 (5-chloro-4-fluoro-2-nitro-phenyl)-carbamic acid tert.-butyl ester 
• 142335-19-1 methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-pyperzinyl)phenylsulfinyl>-3-cyclopropylamine 
• 142335-18-0 methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-ethylaminoacrylate 
• 142335-16-8 methyl 2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinylacetate 

Relevant articles and documents

Novel benzimidazole derivatives; synthesis, bioactivity and molecular docking study as potent urease inhibitors

Background: Benzimidazole derivatives?are?widely?used?to?design and?synthesize?novel bioactive compounds.?There are several approved benzimidazole-based?drugs?on?the?market. Objectives: In this study, we aimed to design and?synthesize?a series of novel benzimidazole derivatives 8a-n?that?are?urease inhibitors. Methods: All 8a-n were synthesized in a multistep. To determine the urease inhibitory effect of 8a-n, the urease inhibition kit was used. The cytotoxicity assay of 8a-n was determined using MTT method. Molecular modelling was determined using autodock software. Results: All?8a-n were synthesized in high yield, and their structures were determined using 1H-NMR, 13C-NMR, MS, and elemental analyses. In compared to thiourea and hydroxyurea as standards (IC50: 22 and 100?μM, respectively), all 8a-n had stronger urease inhibition activity (IC50: 3.36—10.81?μM). With an IC50 value of 3.36?μM, 8e had the best enzyme inhibitory activity. On two evaluated cell lines, the MTT cytotoxicity experiment revealed that all 8a-n have IC50 values greater than 50?μM. Finally, a docking investigation revealed a plausible way of interaction between the 8e and 8d and the enzyme's active site's key residues. Conclusion: The synthesized benzimidazole derivatives exhibit high activity, suggesting that further research on this family of compounds would be beneficial to finding a potent urease inhibitor. Graphical abstract: [Figure not available: see fulltext.]

Design and synthesis of benzothiazole schiff bases of potential antitumor activity

In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.

Quinolonecarboxylic acid derivatives

Quinolonecarboxylic acid derivatives of the following formula, STR1 wherein R1, R2, R3 and R4 are each independently hydrogen atom or lower alkyl group; the hydrates or the pharmaceutically acceptable acid addit