218456-76-9

Usage

Chemical compound

6-chloro-7-fluoro-2,3-diphenylquinoxaline

Class

Quinoxaline derivatives

Characterized by

Quinoxaline core with chlorine and fluorine substitutions at the 6 and 7 positions, two phenyl groups attached at positions 2 and 3

Biological activities

Antibacterial, antifungal, antiviral, anticancer

Potential applications

Medicinal and pharmaceutical research, treatment of neurological disorders, fluorescent probe in bioimaging techniques

Promising candidate for

Further research and development in drug discovery

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 139512-70-2 4-chloro-5-fluorobenzene-1,2-diamine 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 104222-34-6 2-nitro-4-fluoro-5-chloroaniline 
• 81962-58-5 N-(3-chloro-4-fluoro-2-nitrophenyl)acetamide 
• 877-90-7 N-(3-chloro-4-fluorophenyl)acetamide 
• 134-81-6 benzil 

Relevant academic research and scientific papers

Design, synthesis and anti-HIV activity of novel quinoxaline derivatives

In order to design novel anti-HIV agents, pharmacophore modelling, virtual screening, 3D-QSAR and molecular docking studies were performed. Pharmacophore model was generated using 17 structurally diverse molecules using DISCOtech followed by refinement wi

One-step approach for the synthesis of functionalized quinoxalines mediated by T3P-DMSO or T3P: Via a tandem oxidation-condensation or condensation reaction

An easy and efficient propylphosphonic anhydride (T3P)-DMSO or T3P mediated oxidation-condensation or condensation reaction for the synthesis of quinoxalines derived from the interaction of different arrays of condensing partners with ortho-phenylene diamines (o-PDs) under simple and mild reaction conditions in one step has been reported for the first time.

Et3N-catalyzed oxidative dehydrogenative coupling of α-unsubstituted aldehydes and ketones with aryl diamines leading to quinoxalines using molecular oxygen as oxidant

A novel Et3N-catalyzed oxidative dehydrogenative coupling of α-unsubstituted carbonyl compounds with aryl diamines leading to quinoxaline derivatives using molecular oxygen as oxidant has been developed. Six hydrogen dissociations involving 2 sp3 C-H bonds activation are realized under mild conditions in this approach. Plausible mechanism is proposed for this novel Et3N-catalyzed transformation on the basis of the aboratively designed mechanistic studies including the radical detection by EPR. 2012 Elsevier Science. All rights reserved.