81963-44-2

Upstream product

• 81963-42-0 phenylhydrazone of trifluoroacetaldehyde 
• 100-63-0 phenylhydrazine 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 114963-78-9 4-methyl-1-(N-phenyltrifluoroacetohydrazonoyl)pyridinium bromide 
• 966-65-4 1,5-diphenyl-3-trifluoromethyl-2-pyrazoline 
• 134260-12-1 3-trifluoromethyl 7-methyl 1,8,9a-triphenyl 1,4,5,6,7,9a-hexahydro-1,2,4-triazolo<4,3-d><1,4>diazepine 
• 81963-48-6 4-Phenoxymethyl-1-phenyl-3-trifluoromethyl-4,5-dihydro-1H-pyrazole 
• 81963-47-5 5-Phenoxymethyl-1-phenyl-3-trifluoromethyl-4,5-dihydro-1H-pyrazole 
• 81963-56-6 4-Phenoxymethyl-1-phenyl-3-trifluoromethyl-1H-pyrazole 
• 81963-55-5 5-Phenoxymethyl-1-phenyl-3-trifluoromethyl-1H-pyrazole 
• 86539-43-7 C₈H₅F₃N₂ 
• 99498-65-4 3-(trifluoromethyl)-1-phenyl-1H-pyrazole 
• 114963-69-8 5-methylimino-4-phenyl-2-trifluoromethyl-Δ²-1,3,4-thiadiazoline 
• 2730-02-1 1,5-diphenyl-3-(trifluoromethyl)-1H-pyrazole 
• 81963-57-7 2-(1,1,1-trifluoro-4-phenylbut-3-yn-2-ylidene)-1-phenylhydrazine 
• 114963-73-4 4-cyclohexyl-5-cyclohexylimino-1-phenyl-3-trifluoromethyl-Δ²-1,2,4-triazoline 
• 98664-43-8 trans-4,5-dimethoxycarbonyl-1-phenyl-3-trifluoromethyl-2-pyrazoline 

Relevant academic research and scientific papers

A straightforward access to 3-trifluoromethyl-1H-indazoles via (3+2)-cycloaddition of arynes with nitrile imines derived from trifluoroacetonitrile

In situ generated arynes react with nitrile imines derived from trifluoroacetonitrile at 0 °C in THF solutions yielding 3-trifluoromethyl-1H-indazole derivatives as the only intermolecular products. The reaction corresponds the expected (3 + 2)-cycloaddit

Highly fluorinated 2,3-dihydro-1,3,4-thiadiazole derivatives via [3+2]-cycloadditions of tertiary thioamides with nitrile imines derived from trifluoroacetonitrile

Fluorine-rich 1,3,4-thiadiazole derivatives were prepared by 1,3-dipolar cycloaddition of the in situ generated N-aryl-trifluoroacetonitrile imines with tertiary polyfluoroalkanethioamides (N,N-dialkyl thioamides). Reactions were performed under mild cond

Novel trifluoromethylated spiro-1,3,4-thiadiazoles via [3+2]-cycloadditions of 2,3-diphenylcyclopropenethione with selected in situ-generated nitrile imines derived from trifluoroacetonitrile

The in situ-generated N-aryl nitrile imines derived from trifluoroacetonitrile react efficiently with 2,3-diphenylcyclopropenethione to give spirocyclic 1,3,4-thiadiazole derivatives as products of a regio- and chemoselective [3+2]-cycloaddition in good t

Trapping of trifluoroacetonitrile imines with mercaptoacetaldehyde and mercaptocarboxylic acids: An access to fluorinated 1,3,4-thiadiazine derivatives via (3+3)-annulation

The in situ generated highly electrophilic nitrile imines derived from trifluoroacetonitrile are efficiently trapped by monomeric mercaptoacetaldehyde at room temperature in THF solution. The initially formed 1:1 adducts undergo spontaneous cyclization le

Polysubstituted 3-trifluoromethylpyrazoles: Regioselective (3 + 2)-cycloaddition of trifluoroacetonitrile imines with enol ethers and functional group transformations

Non-catalysed addition of trifluoroacetonitrile imines to enol ethers provided fully regioselectively (3 + 2)-cycloadducts, which either spontaneously or via Br?nsted acid-induced elimination of ROH molecules led to the formation of 3-trifluoromethylated

Expected and unexpected results in reactions of fluorinated nitrile imines with (cyclo)aliphatic thioketones

A series of (cyclo)aliphatic thioketones have been tested towards trifluoroacetonitrile imines, generated in situ via base-induced dehydrohalogenation of the respective hydrazonoyl bromides. Typically, non-enolisable thioketones yielded exclusively 3-trif

Trifluoromethylated 2,3-dihydro-1,3,4-thiadiazoles via the regioselective [3+2]-cycloadditions of fluorinated nitrile imines with aryl, hetaryl, and ferrocenyl thioketones

A series of hydrazonoyl bromides prepared from readily available N-arylhydrazones of fluoral was used for the in situ generation of fluorinated nitrile imines. These 1,3-dipoles were efficiently trapped with aryl and hetaryl thioketones yielding fluoromet

Synthesis and Reaction of 5-Amino-3-trifluoromethylisoxazole and -pyrazole-4-carboxylic Acids

5-Amino-3-trifluoromethylisoxazole- and -pyrazole-4-carboxylic acids were prepared by the reactions of trifluoroacetonitrile oxide or -imines with cyanoacetic acid derivatives, respectively.The behavior of thus obtained aminoazole-4-carboxylic acids towar

Cycloadditions of N-Aryl-C-(Trifluoromethyl)nitrilimines with Dimethyl Fumarate and Maleate

The cycloadditions of N-aryl-C-(trifluoromethyl)nitrilimines 1, generated in situ from various precursors, with dimethyl fumarate and maleate are described.N-Aryltrifluoroacetohydrazonoyl bromides 2 reacted with fumarate in the presence of triethylamine to give the trans-4,5-dimethoxycarbonylpyrazolines 4 whereas the reactions with maleate afforded the 4,5-dimethoxycarbonylpyrazoles 5 as well as 4.In the reactions with the chloride 6 under the more drastic conditions, both fumarate and maleate gave the pyrazole 5a.From thermolysis of the oxadiazaphosphole 8, thetrans-pyrazoline 4a was formed in both cases of fumarate and maleate.The preparation of the cis-pyrazoline 9 was attempted from 8 and maleic anhydride but 9 was found to be so unstable as to be epimerized under the mild conditions.

PREPARATION OF TRIFLUOROACETONITRILE PHENYLAMINE AND ITS REACTIONS WITH SOME DIPOLAROPHILES

Trifluoroaceto-N-phenylhydrazonoyl halides, the precursors of trifluoroacetonitrile phenylamine, prepared by halogenation of trifluoroacetaldehyde phenylhydrazon, react with various olefins and acetylenes in the presence of triethylamine to give 3-trifluo