81968-62-9

Usage

Uses

Used in Pharmaceutical Applications:
4(15),5,10(14)-Germacratrien-1-ol is used as an active ingredient for its antifungal and antibacterial properties, making it suitable for the development of treatments targeting fungal and bacterial infections.
Used in Cosmetic Applications:
In the cosmetic industry, 4(15),5,10(14)-Germacratrien-1-ol is used as a natural fragrance component due to its floral and woody scent, enhancing the sensory experience of cosmetic products.
Used in Anti-inflammatory Applications:
4(15),5,10(14)-Germacratrien-1-ol is utilized as an anti-inflammatory agent for its potential to reduce inflammation, which can be beneficial in the treatment of various inflammatory conditions.
Used in Antioxidant Applications:
4(15),5,10(14)-Germacratrien-1-ol is also used as an antioxidant in formulations designed to protect against oxidative stress and related cellular damage, contributing to the maintenance of health and wellness.
Used in Aromatherapy:
4(15),5,10(14)-Germacratrien-1-ol is employed in aromatherapy for its calming and mood-enhancing effects, thanks to its pleasant and natural scent.

Upstream product

• 70560-77-9 (E)-(1R,4S,10R)-4-Isopropyl-1-methyl-7-methylene-11-oxa-bicyclo[8.1.0]undec-5-ene 
• 23986-74-5 germacrene D 
• 105453-16-5 germacrene D 

Downstream Products

• 123163-72-4 (-)-periplanone C 

Relevant academic research and scientific papers

EREMOPHILENE AND GERMACRENE DERIVATIVES FROM SENECIO GLANDULOSO-PILOSUS

Senecio glanduloso-pilosus afforded in addition to known compounds a new eremophilene derivative and a hydroperoxide from germacrene D. - Key Word Index: Senecio glanduloso-pilosus; Compositae; sesquiterpenes; eremophilene derivative; germacrene hydroperoxide.

Enantiomeric Resolution of a Germacrene-D Derivative by Chiral High-performance Liquid Chromatography

Direct enantiomeric resolution of the germacrene-D derivative, (5E,7S*,9S*)-9-hydroxy-7-isopropyl-4,10-bis(methylene)-5-cyclodecen- 1-one, was carried out by HPLC with a chiral stationary phase. This method showed that germacrene-D contained in ylang ylang oil was 98% e.e., whereas germacrene-D extracted from Solidago altissima L. was almost racemic.

Total synthesis of (-)-periplanones C and D. Their pheromonal activities against three Periplaneta species

Total synthesis of(-)-periplanones C [(-)-PC; 1] and D [(-)-PD; 2] was achieved starting from (-)-germacrene D via 7 and 8 steps, respectively, according to the similar route on syntheses of racemic PC and PD. The 1H NMR and GC mass spectra of 2 unambiguously determined the structure of the natural sample of PD which was isolated from Periplaneta fuliginosa. Bioassay of synthetic samples of 1 and 2 was carried oat against males of P. fuliginosa, P. americana, and P. japonica. 10-9 g of 1 elicited significant response in males of P. americana and P. japonica. 10-10 g of 2 elicited strong response in P. fuliginosa males, whereas it showed significantly weak response against males of P. americana and P. japonica. Almost same degree of activities was observed between 1 and 2 against males of P. americana and P. japonica at 10-10 g dose.

THE SYNTHESIS OF A TRICYCLIC HYDROAZULENONE FROM EXO-EPOXYGERMACRENE-D IN CONNECTION WITH PERIPLANONE A

In connection with periplanone A, acid-catalyzed reaction of germacrene-D epoxide has been carried out using AlCl3 in ether to afford a hydroazulene which has been further transformed into one of the hydroazulenones proposed to be periplanone A.

Constituents of Torilis japonica D.C. I. Isolation and Optical Purity of Germacra-4(15),5(E),10(14)-trien-1β-ol

Humulene (I), (-)-germacrene-D (II), and (-)-germacra-4(15),5(E),10(14)-trien-1β-ol (III) were isolated from the fruits of Torilis japonica.The latter two compounds (II and III) were determined to have optical purities of about 40 and 30percent, respectively.Keywords-Torilis japonica; humulene; germacrene-D; germacra-4(15),5(E),10(14)-trien-1β-ol; optical purity