81972-06-7

Upstream product

• 6277-13-0 3-ethoxycarbonyl-4-methylpyrrole-2-carboxylic acid 
• 100-44-7 benzyl chloride 
• 975-45-1 benzyl 3-methyl-4-(ethoxycarbonyl)-5-carboxy-2-pyrrolecarboxylate 
• 81972-02-3 benzyl 3-methyl-4-(ethoxycarbonyl)-5-(tert-butoxycarbonyl)-2-pyrrolecarboxylate 
• 81972-03-4 tert-butyl 3-(ethoxycarbonyl)-4-methyl-5-carboxy-2-pyrrolecarboxylate 
• 81972-04-5 5-Iodo-4-methyl-1H-pyrrole-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester 
• 81972-05-6 tert-butyl 3-(ethoxycarbonyl)-4-methyl-2-pyrrolecarboxylate 
• 141-97-9 ethyl acetoacetate 
• 68999-91-7 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 2-benzyl ester 4-ethyl ester 

Downstream Products

• 81972-07-8 benzyl 3-(ethoxycarbonyl)-4-methyl-5-formyl-2-pyrrolecarboxylate 
• 81972-08-9 benzyl 3-(ethoxycarbonyl)-4-methyl-5-(hydroxymethyl)-2-pyrrolecarboxylate 
• 81972-09-0 dibenzyl 3,4'-bis(ethoxycarbonyl)-3',4-dimethyldipyrrylmethane-5,5'-dicarboxylate 

Relevant academic research and scientific papers

Carbon-5 Regiospecific Synthesis of Deuteroporphyrin IX

Benzyl 3-(ethoxycarbonyl)-4-methyl-2-pyrrolecarboxylate was formylated with dimethylformamide (DMF)-phosphorous oxychloride, and the 5-formylpyrrole was obtained in 50percent yield.It was reduced with sodium borohydride to the alcohol, which was condensed with benzyl 3-methyl-4-(ethoxycarbonyl)-2-pyrrolecarboxylate to afford dibenzyldipyrrylmethane in good yield.The latter was transformed into its 5,5'-diformyl derivative which when condensed with bis-4-methylpyrryl>methane afforded the 3,8-bis(ethoxycarbonyl)deuteroporphyrin IX dimethyl ester in 40percent yield.Decarboxylation of the latter in hot hydrochloric acid gave deuteroporphyrin IX (isolated as its dimethyl ester) in 50percent yield.