6277-13-0

Usage

Uses

Used in Pharmaceutical Research:
3-(ethoxycarbonyl)-4-methyl-1H-pyrrole-2-carboxylic acid is used as a building block for the development of new drugs, contributing to the creation of diverse chemical structures with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 3-(ethoxycarbonyl)-4-methyl-1H-pyrrole-2-carboxylic acid serves as an intermediate in the synthesis of complex organic molecules, facilitating the formation of a wide range of chemical entities with various applications.
Safety Considerations:
It is crucial to handle 3-(ethoxycarbonyl)-4-methyl-1H-pyrrole-2-carboxylic acid with proper care and adhere to safety guidelines to mitigate its potential hazards.

Upstream product

• 81972-05-6 tert-butyl 3-(ethoxycarbonyl)-4-methyl-2-pyrrolecarboxylate 
• 7737-17-9 1-aminopropan-2-one hydrochloride 
• 108-56-5 diethyl oxaloacetate 
• 975-45-1 benzyl 3-methyl-4-(ethoxycarbonyl)-5-carboxy-2-pyrrolecarboxylate 
• 81972-04-5 5-Iodo-4-methyl-1H-pyrrole-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester 
• 68999-91-7 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 2-benzyl ester 4-ethyl ester 
• 298-08-8 glycine methyl ketone 
• 81972-02-3 benzyl 3-methyl-4-(ethoxycarbonyl)-5-(tert-butoxycarbonyl)-2-pyrrolecarboxylate 
• 141-97-9 ethyl acetoacetate 
• 81972-03-4 tert-butyl 3-(ethoxycarbonyl)-4-methyl-5-carboxy-2-pyrrolecarboxylate 

Downstream Products

• 64276-66-0 4-methyl-1H-pyrrole-3-carboxylic acid 
• 18711-59-6 4-methyl-1H-pyrrole-2-carboxylic acid 
• 34402-78-3 methyl 4-methyl-1H-pyrrole-2-carboxylate 
• 81972-09-0 dibenzyl 3,4'-bis(ethoxycarbonyl)-3',4-dimethyldipyrrylmethane-5,5'-dicarboxylate 
• 81972-07-8 benzyl 3-(ethoxycarbonyl)-4-methyl-5-formyl-2-pyrrolecarboxylate 
• 81972-08-9 benzyl 3-(ethoxycarbonyl)-4-methyl-5-(hydroxymethyl)-2-pyrrolecarboxylate 
• 6339-66-8 ethyl 5-formyl-4-methyl-1H-pyrrole-3-carboxylate 
• 2199-49-7 ethyl 4-methylpyrrole-3-carboxylate 
• 81972-06-7 benzyl 3-(ethoxycarbonyl)-4-methyl-2-pyrrolecarboxylate 

Relevant academic research and scientific papers

Efficient synthesis of an A-B-C-tricycle fragment for a structural model of tolyporphin

An efficient stereocontrolled synthesis of an A-B-C-tricycle fragment 7 for a structural model of tolyporphin 3 is described. All the rings were prepared from readily available starting materials. One of the two key steps is a selective ring-opening reaction of the lactone cycle in bicyclolactam-lactone 17 to cyanopyrrolidone 18, which introduces the chirality into synthetic compounds. The other key step is the combination of A ring with B-C-bicycle via a two-time Eschenmoser sulfide contraction. A-B-C-tricycle fragment 7 allows a new approach toward tolypophin compounds and other uroporphinoids.

Carbon-5 Regiospecific Synthesis of Deuteroporphyrin IX

Benzyl 3-(ethoxycarbonyl)-4-methyl-2-pyrrolecarboxylate was formylated with dimethylformamide (DMF)-phosphorous oxychloride, and the 5-formylpyrrole was obtained in 50percent yield.It was reduced with sodium borohydride to the alcohol, which was condensed with benzyl 3-methyl-4-(ethoxycarbonyl)-2-pyrrolecarboxylate to afford dibenzyldipyrrylmethane in good yield.The latter was transformed into its 5,5'-diformyl derivative which when condensed with bis-4-methylpyrryl>methane afforded the 3,8-bis(ethoxycarbonyl)deuteroporphyrin IX dimethyl ester in 40percent yield.Decarboxylation of the latter in hot hydrochloric acid gave deuteroporphyrin IX (isolated as its dimethyl ester) in 50percent yield.