81982-49-2Relevant academic research and scientific papers
SUBSTITUTED PYRAZOLE AND TRIAZOLE COMPOUNDS AS KSP INHIBITORS
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Page/Page column 73, (2008/12/05)
Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses thereof
A Remarkably Simple Route to Versatile Difluoromethylated Molecules
Kaneko, Sadanori,Yamazaki, Takashi,Kitazume, Tomoya
, p. 2302 - 2312 (2007/10/02)
Difluoroacetaldehyde ethyl hemiacetal (1), prepared from ethyl difluoroacetate and lithium aluminum hydride in diethyl ether, was found to be a potential difluoroethylating reagent for the preparation of a wide variety of difluoromethylated compounds.Compound 1 shows promise for use in the synthesis of carbinols prepared by the reaction of 1 with metal reagents or enol silyl ethers, the synthesis of amino acid ketones and β-lactams via the nucleophilic reaction of imines, and the synthesis of sugar analogues.
Fluorinated diaminobutane derivatives
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, (2008/06/13)
Fluorinated diaminobutane compounds in vivo are inhibitors of gamma-aminobutyric acid transaminase and have the following formula: STR1 wherein: R1 represents hydrogen, C1 -C6 alkyl, or phenyl-(C1 -C4 alkyl); R2 represents hydrogen, C1 -C6 alkyl, phenyl-(C1 -C4 alkyl), or R4, where R4 is as defined below; R3 represents hydrogen, or, except when R2 represents R4, R4, where R4 is as defined below; each R4, independently, represents C2 -C5 alkylcarbonyl, phenylcarbonyl, phenyl-(C1 -C4 alkyl) carbonyl, or an aminocarboxylic acid residue derived by removal of an hydroxy group from the carboxy moiety of an L-aminocarboxylic acid; and p represents 1 or 2, and pharmaceutically acceptable acid addition salts thereof.
