819849-41-7

Basic information

• Product Name: 3'-(4-azidophenyl)-2'-tert-butyldimethylsiloxy-3'-dephenyl-7-triethylsiloxypaclitaxel
• Synonyms: 3'-(4-azidophenyl)-2'-tert-butyldimethylsiloxy-3'-dephenyl-7-triethylsiloxypaclitaxel
• CAS NO: 819849-41-7
• Molecular Weight: 1123.46
• Mol File: 819849-41-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3'-(4-azidophenyl)-2'-tert-butyldimethylsiloxy-3'-dephenyl-7-triethylsiloxypaclitaxel(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-(4-azidophenyl)-2'-tert-butyldimethylsiloxy-3'-dephenyl-7-triethylsiloxypaclitaxel(819849-41-7)
• EPA Substance Registry System: 3'-(4-azidophenyl)-2'-tert-butyldimethylsiloxy-3'-dephenyl-7-triethylsiloxypaclitaxel(819849-41-7)

Safety Data

• Hazardous Substances Data: 819849-41-7(Hazardous Substances Data)

Upstream product

• 819849-37-1 (4S,3R)-4-[4-(azidophenyl)]-3-tert-butyldimethylsiloxy-1-(4-methoxyphenyl)azetidin-2-one 
• 819849-36-0 (4S,3R)-4-(4-azidophenyl)-3-hydroxy-1-(4-methoxyphenyl)azetidin-2-one 
• 819849-38-2 (4S,3R)-4-[4-(azidophenyl)]-3-tert-butyldimethylsiloxyazetidin-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 31499-54-4 4-azidobenzyl alcohol 
• 623-04-1 4-aminobenzenemethanol 
• 115437-21-3 7-(triethylsilyl)baccatin III 
• 819849-39-3 (4S,3R)-4-[4-(azidophenyl)]-3-tert-butyldimethylsiloxy-1-(phenylcarbonyl)azetidin-2-one 
• 819849-34-8 (4S,3R)-4-(4-azidophenyl)-1-(4-methoxyphenyl)-2-oxoazetidin-3-yl acetate 

Relevant articles and documents

Synthesis and anti-tubulin activity of a 3′-(4-Azidophenyl)-3′- dephenylpaclitaxel photoaffinity probe

The synthesis and biological evaluation of a novel paclitaxel photoaffinity probe is described. The synthesis involved the preparation of an azide-containing C13 side chain through a Staudinger cycloaddition followed by a lipase-mediated kinetic resolution to obtain the azetidinone in 99% ee. Coupling of the enantiopure side chain precursor to 7-TES-baccatin III and subsequent silyl ether deprotection afforded 3′-(4-azidophenyl)-3′- dephenylpaclitaxel, which was shown to be as active as paclitaxel in tubulin assembly and cytotoxicity assays.