81990-65-0Relevant academic research and scientific papers
A ONE-STEP SYNTHESIS OF PURINE DERIVATIVES BY THE REACTION OF PHENYLAZOMALONAMIDAMIDINE WITH ARYL ALDEHYDES
Yoneda, Fumio,Koga, Ryosuke,Higuchi, Masatsugu
, p. 365 - 368 (2007/10/02)
Treatment of phenylazomalonamidamidine (I) with aryl aldehydes yielded the corresponding 2,8-diarylhypoxanthines (II) in single step.The reaction under milder conditions formed the intermediary monoarylidene derivatives (III) of I, from which the corresponding 6-amino-2-aryl-5-phenylazopyrimidine-4(3H)-ones (IV) were obtained by the oxidative cyclization with diethyl azodicarboxylate.Treatment of IV with second aryl aldehydes gave the unsymmetrical 2,8-diarylated hypoxanthines.
