6285-64-9

Basic information

• Product Name: 2-FORMAMIDINO-2-PHENYLDIAZOACETAMIDE HYDROCHLORIDE
• Synonyms: 2-FORMAMIDINO-2-PHENYLDIAZOACETAMIDE HYDROCHLORIDE;2-Formamidino-2-phenyldiazoacetamide;3-Amino-3-imino-2-(phenylazo)propanamide monohydrochloride;PropanaMide, 3-aMino-3-iMino-2-(2-phenyldiazenyl)-, hydrochloride;3-Amino-3-imino-2-(2-phenyldiazenyl)propanamide Hydrochloride;phenylazomalonamamidine hydrochloride;2-FORMAMIDINO-2-PHENYLDIAZOACETAMIDE HYDROCHL;Temozolomide INT
• CAS NO: 6285-64-9
• Molecular Formula: C₉H₁₁N₅O*ClH
• Molecular Weight: 242.665
• Mol File: 6285-64-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 349.2°C at 760 mmHg
• Flash Point: 165°C
• Appearance: /
• Density: 1.4g/cm³
• Vapor Pressure: 4.76E-05mmHg at 25°C
• Refractive Index: 1.664
• CAS DataBase Reference: 2-FORMAMIDINO-2-PHENYLDIAZOACETAMIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FORMAMIDINO-2-PHENYLDIAZOACETAMIDE HYDROCHLORIDE(6285-64-9)
• EPA Substance Registry System: 2-FORMAMIDINO-2-PHENYLDIAZOACETAMIDE HYDROCHLORIDE(6285-64-9)

Safety Data

• Hazardous Substances Data: 6285-64-9(Hazardous Substances Data)

Usage

Uses

3-Amino-3-imino-2-(2-phenyldiazenyl)propanamide Hydrochloride is a Temozolomide (T017775) impurity. Temozolomide acts as a imidazotetrazine alkylating agent. An antineoplastic.

InChI:InChI=1/C9H11N5O/c10-8(11)7(9(12)15)14-13-6-4-2-1-3-5-6/h1-5,7H,(H3,10,11)(H2,12,15)/b14-13+

Upstream product

• 100-34-5 benzene diazonium chloride 
• 34570-17-7 malonamamidine hydrochloride 

Downstream Products

• 81976-27-4 2,8-Bis-(3-chloro-phenyl)-1,7-dihydro-purin-6-one 
• 81976-31-0 2,8-Di-m-tolyl-1,7-dihydro-purin-6-one 
• 81976-33-2 2-{N-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-carbamimidoyl}-2-phenylazo-acetamide; hydrochloride 
• 81976-28-5 2,8-Bis-(3,4-dichloro-phenyl)-1,7-dihydro-purin-6-one 
• 81990-66-1 2-{N-[1-(4-Bromo-phenyl)-meth-(E)-ylidene]-carbamimidoyl}-2-phenylazo-acetamide; hydrochloride 
• 81976-29-6 2,8-Bis-(4-bromo-phenyl)-1,7-dihydro-purin-6-one 
• 81976-32-1 2-Phenylazo-2-{N-[1-phenyl-meth-(E)-ylidene]-carbamimidoyl}-acetamide; hydrochloride 
• 54013-62-6 2,8-diphenyl-1,7-dihydro-purin-6-one 
• 81990-65-0 2-{N-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-carbamimidoyl}-2-phenylazo-acetamide; hydrochloride 
• 81976-26-3 2,8-di(p-chlorophenyl)-hypoxanthine 
• 81976-30-9 2,8-Di-p-tolyl-1,7-dihydro-purin-6-one 

Relevant articles and documents

Xanthine oxidase (XO): Relative configuration of complexes formed by the enzyme, 2- or 8-N-alkylhypoxanthines and 2-N-alkyl-8-azahypoxanthines. XII

Several 2- or 8-n-alkyl-hypoxanthines and a 2,8-di-n-pentylhypoxanthine were synthesized and tested as substrates or inhibitors of Xanthine Oxidase (XO). 8-Alkyl derivatives showed a substrate behaviour, whereas 2-alkyl substituted compounds were non-substrates and inhibitors. 2,8-di-n-pentylhypoxanthine was ineffective as inhibitor. The comparison between their activity allowed us to conclude that the complexes formed by the enzyme and the cited n-alkylhypoxanthines or 2-n -alkyl-8-azahypoxanthines involve their N(3) and N(9) positions in all the cases. The position of the n-alkyl chain determines the disposition of the molecule inside the complex: 2-n-alkyl-hypoxanthines and 2-n-alkyl-8-azahypoxanthines gave complexes with the same orientation of heterocyclic moieties, opposite that given by 8-n-alkyl-hypoxanthines.