82018-88-0Relevant academic research and scientific papers
Synthesis of 3-(2-Olefinbenzyl)-4H-chromen-4-one through Cyclobenzylation and Catalytic C-H Bond Functionalization Using Palladium(II)
Lin, Yu-Feng,Fong, Chi,Peng, Wan-Ling,Tang, Kuei-Chien,Liang, Yi-En,Li, Wen-Tai
, p. 10855 - 10865 (2017/10/27)
An efficient strategy for synthesizing 3-(2-olefinbenzyl)-4H-chromen-4-one in two steps was developed. The first step is a cyclobenzylation reaction between (E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one and benzyl bromide to produce homoisoflav
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach
Cavalli, Andrea,Bisi, Alessandra,Bertucci, Carlo,Rosini, Carlo,Paluszcak, Anja,Gobbi, Silvia,Giorgio, Egidio,Rampa, Angela,Belluti, Federica,Piazzi, Lorna,Valenti, Piero,Hartmann, Rolf W.,Recanatini, Maurizio
, p. 7282 - 7289 (2007/10/03)
To identify enantioselective nonsteroidal aromatase inhibitors, a multidisciplinary medicinal chemistry approach was pursued. First, our earlier CoMFA model [Bioorg. Med. Chem. 1998, 6, 377-388] was extended taking purposely into account previously discov
Reactivity of α-arylidene benzoheteracyclanone dibromides toward azide ion: An effective approach to 3-(α-substituted-benzyl)chromones and -1-thiochromones
Patonay,Dinya,Lévai,Molnár
, p. 2895 - 2907 (2007/10/03)
Treatment of dibromides of 3-arylidenechromanones and -1-thiochromanones with sodium azide resulted in the formation of 3-(α-azidobenzyl)chromones and -1-thiochromones whereas dibromides having no antiperiplanar vicinal hydrogen in the ring such as flavanone, 1-thioflavanone and benzosuberone derivatives afforded only the parent enones by bromine elimination. Evidence supported the intermediacy of 3-(α-bromobenzyl)chromones and -1-thiochromones in this reaction. These postulated intermediates were prepared in an independent way and transformed into azides in high yield.
