82023-29-8

Usage

InChI:InChI=1/C12H7FN2O4/c13-8-5-14-12(18)15(9(8)16)10-6-3-1-2-4-7(6)11(17)19-10/h1-5,10H,(H,14,18)

Upstream product

• 82033-51-0 3-(1,3-dihydro-3-oxo-isobenzofuran-1-yl)-1-(2,2,2-trichloroethoxycarbonyl)-5-fluorouracil 
• 82104-77-6 1,3-bis(1,3-dihydro-3-oxoisobenzofuran-1-yl)-5-fluorouracil 
• 51-21-8 5-fluorouracil 
• 6940-49-4 3-Bromophthalide 
• 90162-91-7 5-Fluoro-2,4-dioxo-3-(3-oxo-1,3-dihydro-isobenzofuran-1-yl)-3,4-dihydro-2H-pyrimidine-1-carbothioic acid S-octyl ester 
• 104861-76-9 5-Fluoro-2,4-dioxo-3-(3-oxo-1,3-dihydro-isobenzofuran-1-yl)-3,4-dihydro-2H-pyrimidine-1-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Studies on the Synthesis of Chemotherapeutics. 12. Synthesis and Antitumor Activity of N-Phthalidyl-5-fluorouracil Derivatives

Several N-phthalidyl-5-fluorouracil derivatives were synthesized for preliminary antitumor evaluation.N1-Phthalidyl- and N3-phthalidyl-5-fluorouracils (6 and 10) showed a significant antitumor activity against experimental solid tumors with a good blood l

N-Phthalidyl-5-fluorouracils

The present invention relates to novel N-phthalidyl-5-fluorouracil derivatives represented by the general formula STR1 wherein one of R1 and R2 represents phthalidyl group STR2 (wherein R3 is a hydrogen atom, a halogen atom or a group selected from alkoxyl groups or alkyl groups) and the other represents a hydrogen atom, an acyl group or a cyclic ether group; STR3 (wherein n is 1 or 2) or R1 and R2 represent the same phthalidyl group; STR4 (wherein R3 has the same meaning as that defined above) and provides a compound which has antitumor activity and less toxicity and can be used as a cancerocidal agent.

5-FLUOROURACIL DERIVATIVES. VI. ALKYLATION OF 5-FLUOROURACIL USING THE (OCTYLTHIO)CARBONYL GROUP AS A PROTECTING FUNCTION

N1- and N3-alkyl-5-fluorouracils are prepared in good yields by the alkylation of 5-fluorouracil protected by the (octylthio)carbonyl group.