Studies on the Synthesis of Chemotherapeutics. 12. Synthesis and Antitumor Activity of N-Phthalidyl-5-fluorouracil Derivatives

DOI: 10.1021/jm00352a024

Source and publish data:

Journal of Medicinal Chemistry p. 1219 - 1222 (1982)

Update date:2022-08-18

Topics:

Authors:

Kametani, Tetsuji

Kigasawa, Kazuo

Hiiragi, Mineharu

Wakisaka, Kikuo

Nakazato, Kikuo

et al. et al.

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Article abstract of DOI:10.1021/jm00352a024

Several N-phthalidyl-5-fluorouracil derivatives were synthesized for preliminary antitumor evaluation.N1-Phthalidyl- and N3-phthalidyl-5-fluorouracils (6 and 10) showed a significant antitumor activity against experimental solid tumors with a good blood l

Full text of DOI:10.1021/jm00352a024

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