820236-81-5

Basic information

• Product Name: Methyl 2-bromo-6-fluorobenzoate
• Synonyms: Methyl 2-bromo-6-fluorobenzoate
• CAS NO: 820236-81-5
• Molecular Formula: C₈H₆BrFO₂
• Molecular Weight: 233.0344432
• Mol File: 820236-81-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: Methyl 2-bromo-6-fluorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-bromo-6-fluorobenzoate(820236-81-5)
• EPA Substance Registry System: Methyl 2-bromo-6-fluorobenzoate(820236-81-5)

Safety Data

• Hazardous Substances Data: 820236-81-5(Hazardous Substances Data)

Usage

General Description

Methyl 2-bromo-6-fluorobenzoate is a chemical compound with the molecular formula C8H6BrFO2. It is a derivative of benzoic acid and belongs to the class of bromo-fluoro compounds. Methyl 2-bromo-6-fluorobenzoate is commonly used in organic synthesis and medicinal chemistry as a building block for the production of various pharmaceuticals and agrochemicals. Methyl 2-bromo-6-fluorobenzoate has potential applications in the development of new drugs and can also be used as a reagent in chemical reactions for the synthesis of complex organic molecules. It is important to handle this chemical with care, as it may pose certain hazards if not used properly.

InChI:InChI=1/C8H6BrFO2/c1-12-8(11)7-5(9)3-2-4-6(7)10/h2-4H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 2252-37-1 2-bromo-6-fluorobenzoic acid 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 77-78-1 dimethyl sulfate 
• 851368-08-6 1-bromo-2-fluoro-6-iodobenzene 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 1073-06-9 3-fluorobromobenzene 

Downstream Products

• 1352133-13-1 methyl 2-cyclopropyl-6-fluorobenzoate 
• 1352133-14-2 (2-cyclopropyl-6-fluorophenyl)-methanol 
• 1352133-15-3 2-chloromethyl-1-cyclopropyl-3-fluorobenzene 
• 1352133-16-4 6-bromo-8-(2-cyclopropyl-6-fluoro-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1352133-17-5 6-bromo-8-(2-cyclopropyl-6-fluorobenzyl)-2-methanesulfinyl-8H-pyrido [2,3-d]pyrimidin-7-one 
• 1352133-18-6 6-bromo-8-(2-cyclopropyl-6-fluorobenzyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1352132-86-5 8-(2-cyclopropyl-6-fluorobenzyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-6-prop-1-ynyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1352132-87-6 8-(2-cyclopropyl-6-fluorobenzyl)-6-ethynyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1256593-43-7 methyl 2-fluoro-6-formylbenzoate 

Relevant articles and documents

Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid

The YAP-TEAD transcriptional complex is responsible for the expression of genes that regulate cancer cell growth and proliferation. Dysregulation of the Hippo pathway due to overexpression of TEAD has been reported in a wide range of cancers. Inhibition of TEAD represses the expression of associated genes, demonstrating the value of this transcription factor for the development of novel anti-cancer therapies. We report herein the design, synthesis and biological evaluation of LM98, a flufenamic acid analogue. LM98 shows strong affinity to TEAD, inhibits its autopalmitoylation and reduces the YAP-TEAD transcriptional activity. Binding of LM98 to TEAD was supported by 19F-NMR studies while co-crystallization experiments confirmed that LM98 is anchored within the palmitic acid pocket of TEAD. LM98 reduces the expression of CTGF and Cyr61, inhibits MDA-MB-231 breast cancer cell migration and arrests cell cycling in the S phase during cell division.

COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR

The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical compsosition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Synthesis and structure-activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs

An efficient total synthesis of the potent V-ATPase inhibitor saliphenylhalamide (SaliPhe), a synthetic variant of the natural product salicylihalamide A (SaliA), has been accomplished aimed at facilitating the development of SaliPhe as an anticancer and antiviral agent. This new approach enabled facile access to derivatives for structure-activity relationship studies, leading to simplified analogs that maintain SaliPhe's biological properties. These studies will provide a solid foundation for the continued evaluation of SaliPhe and analogs as potential anticancer and antiviral agents.