820239-44-9Relevant articles and documents
Design and synthesis of a new series of 3,5-disubstituted-1,2,4-oxadiazoles as potential colchicine binding site inhibitors: Antiproliferative activity, molecular docking, and SAR studies
Abdel-Aal, Eatedal H.,Abdel-Sami, Zakaria K.,Abo-Dya, Nader E.,Al-Karmalawy, Ahmed A.,Diab, Rana T.
, p. 21657 - 21669 (2021/12/09)
The development of anticancer compounds targeting the colchicine-binding site of tubulin, termed colchicine-binding site inhibitors (CBSIs) is a promising research area for pharmaceutical companies and research institutes. A series of 3,5-disubstituted 1,
Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates
Ibrahim, Mohamed A.,Panda, Siva S.,Birs, Antoinette S.,Serrano, Juan C.,Gonzalez, Claudio F.,Alamry, Khalid A.,Katritzky, Alan R.
, p. 1856 - 1861 (2014/04/17)
Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and L
Non-phosgene route to unsymmetrical ureas from N-Cbz-α-amino acid amides
Ghazvini Zadeh, Ebrahim H.,Abo-Dya, Nader E.,Sotuyo, Ania C.,Ghiviriga, Ion,Hall, C. Dennis
, p. 5467 - 5469 (2013/09/23)
A convenient method toward the synthesis of α-amino acid-derived unsymmetrical ureas 2 is described herein. This route involves an interesting rearrangement of amides of N-Cbz-α-amino acids 1, which presumably entails the intermediacy of hydantoins that is followed by hydrolysis to afford unsymmetrical ureas 2 in quantitative yields and high purity.
