82024-51-9Relevant academic research and scientific papers
A very concise synthesis of a potent N-(1,3-thiazol-2-yl)pyridin-2-amine KDR kinase inhibitor
Zhao, Matthew,Yin, Jingjun,Huffman, Mark A.,McNamara, James M.
, p. 1110 - 1115 (2007/10/03)
A very concise synthesis of a potent KDR kinase inhibitor 1 is described. The synthesis features an exceedingly efficient one-pot preparation of the aminothiazole 6 followed by Pd-Xantphos catalyzed cross-coupling with chloropyridine aldehyde 11. Reductiv
