820244-29-9

Upstream product

• 186581-53-3 diazomethane 
• 820244-27-7 4-methyl-5-[methyl(phenyl)amino]-5-oxopentanoic acid 
• 820244-25-5 5-hydroxy-2,N-dimethyl-N-phenylpentanamide 
• 73746-79-9 α-methyl-δ-valerolactone 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 

Downstream Products

• 820244-31-3 methyl 4-methyl-5-[methyl(phenyl)amino]-5-thioxopentanoate 
• 820244-35-7 methyl (RS)-4-[((S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]-4-methyl-5-[methyl(phenyl)amino]-5-oxopentanoate 
• 820244-45-9 methyl 3-[(RS)-2-((S)-1-{[(benzyloxy)carbonyl]amino}-2-methylpropyl)-4-methyl-5-oxo-1,3-oxazol-4-yl]propanoate 
• 820244-21-1 methyl 3-(3-amino-2,N-dimethyl-N-phenyl-2H-azirin-2-yl)propanoate 

Relevant academic research and scientific papers

A new 2H-azirin-3-amine as a synthon for α-methyl glutamate

The synthesis of a novel 2,2-disubstituted 2H-azirin-3-amine 10 as a building block for racemic Glu(2Me) is described. This synthon contains an ester group in the side chain. The reaction of 10 with thiobenzoic S-acid and the amino acid Z-Val-OH yielded the racemic monothiodiamide 17 and the dipeptide 18 as a mixture of diastereoisomers, respectively (Scheme 2). From 18, each of the protecting groups was removed selectively (Scheme 3).