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α-Hydroxy-α-methyl-4-(trifluoromethyl)benzeneacetonitrile is a complex organic compound with the molecular formula C10H8F3NO. It features a benzene ring with a trifluoromethyl group at the 4-position, an α-methyl group, and an α-hydroxyl group attached to the acetonitrile functional group. α-hydroxy-α-methyl-4-(trifluoromethyl)benzeneacetonitrile is known for its potential applications in the synthesis of pharmaceuticals and agrochemicals, particularly as a building block for the creation of various active ingredients. Its unique structure, which includes the electron-withdrawing trifluoromethyl group and the hydrogen-bonding hydroxyl group, can significantly influence its reactivity and interactions with other molecules, making it a valuable intermediate in organic synthesis.

82026-76-4

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82026-76-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 82026-76-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,0,2 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 82026-76:
(7*8)+(6*2)+(5*0)+(4*2)+(3*6)+(2*7)+(1*6)=114
114 % 10 = 4
So 82026-76-4 is a valid CAS Registry Number.

82026-76-4Relevant academic research and scientific papers

Bifunctional Metal-Organic Layers for Tandem Catalytic Transformations Using Molecular Oxygen and Carbon Dioxide

Jiang, Xiaomin,Lan, Guangxu,Lin, Wenbin,Ni, Kaiyuan,Quan, Yangjian,Shi, Wenjie,Song, Yang,Wang, Cheng

supporting information, p. 16718 - 16724 (2021/10/21)

Tandem catalytic reactions improve atom- and step-economy over traditional synthesis but are limited by the incompatibility of the required catalysts. Herein, we report the design of bifunctional metal-organic layers (MOLs), HfOTf-Fe and HfOTf-Mn, consisting of triflate (OTf)-capped Hf6 secondary building units (SBUs) as strong Lewis acidic centers and metalated TPY ligands as metal active sites for tandem catalytic transformations using O2 and CO2 as coreactants. HfOTf-Fe effectively transforms hydrocarbons into cyanohydrins via tandem oxidation with O2 and silylcyanation whereas HfOTf-Mn converts styrenes into styrene carbonates via tandem epoxidation and CO2 insertion. Density functional theory calculations revealed the involvement of a high-spin FeIV (S = 2) center in the challenging oxidation of the sp3 C-H bond. This work highlights the potential of MOLs as a tunable platform to incorporate multiple catalysts for tandem transformations.

Influence of an α-Cyano Function on Charge Delocalization in the Benzyl Cation. Relationship between Inductive Destabilization and Conjugative Stabilization by the Cyano Group

Gassman, Paul G.,Guggenheim, Thomas L.

, p. 3023 - 3026 (2007/10/02)

The solvolytic behavior of a series of substituted acetophenone cyanohydrin methanesulfonates has been studied in 2,2,2-trifluoroethanol.A ρ value of -6.70 was observed when the rate data was evaluated vs.Brown's ?+ values.

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