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82034-46-6

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Loteprednol Etabonate
Cas No: 82034-46-6
No Data 5 Gram we have enough ingredient Metric Ton/Day Hunan Warrant Pharmaceutical Co.,Lcd Contact Supplier
Loteprednol etabonate
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loteprednol etabonate CAS 82034-46-6
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High purity 82034-46-6 Loteprednol Etabonate
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Loteprednol etabonate
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No Data No Data No Data Simagchem Corporation Contact Supplier
17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylic acid chloromethyl ester
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loteprednol etabonate
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82034-46-6 Usage

Uses

Biological Activity Chemical Information Tech Support & FAQs Biological Activity Loteprednol etabonate is an anti-inflammatory corticosteroid used in ophthalmology. It is used for the treatment of steroid responsive inflammatory conditions of the eye su

Description

Loteprednol (as Loteprednol Etabonate) is a topical anti-inflammatory corticosteroid. Loteprednol etabonate (LE) has a 17α-chloromethyl ester, in lieu of a ketone group, and a 17β-etabonate group. LE is highly lipophilic and binds with high affinity to the glucocorticoid receptor. Any unbound LE is metabolized to inactive metabolites.
Loteprednol etabonate is used in ophthalmic solution for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitis. It is used in ophthalmic ointment for the treatment of post-operative inflammation and pain following ocular surgery. As a nasal spray, it is used for the treatment and management of seasonal allergic rhinitis.

Chemical Properties

x

References

[1] http://www.webmd.com
[2] https://www.drugbank.ca
[3] http://www.bausch.com
[4] Timothy L. Comstock, Heleen H. DeCory (2012) Advances in Corticosteroid Therapy for Ocular Inflammation: Loteprednol Etabonate, International Journal of Inflammation, 2012, 789623
[5] N. Krug, JM. Hohlfeld, H. Geldmacher, M Larbig, R. Heermann, N. Lavallee, DT. Nguyen, U. Petzold, R. Hermann (2005) Effect of loteprednol etabonate nasal spray suspension on seasonal allergic rhinitis assessed by allergen challenge in an environmental exposure unit, Allergy, 60, 354-359

Uses

An ophthalmic corticosteroid. Used as an anti-inflammatory

Brand name

Alrex (Bausch & Lomb); Lotemax (Bausch & Lomb); Lotemax (Pharmos).
InChI:InChI=1/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16-,17-,18-,19+,22-,23-,24-/m0/s1

82034-46-6 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (SML0547)  Loteprednol Etabonate  ≥98% (HPLC) 82034-46-6 SML0547-50MG 3,192.93CNY Detail
Sigma (SML0547)  Loteprednol Etabonate  ≥98% (HPLC) 82034-46-6 SML0547-10MG 788.58CNY Detail

82034-46-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name loteprednol etabonate

1.2 Other means of identification

Product number -
Other names loteprednol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:82034-46-6 SDS

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