82040-26-4

Upstream product

• 369-36-8 6-fluoro-3-nitroaniline 
• 41939-61-1 N₁-methyl-4-nitrobenzene-1,2-diamine 
• 99-81-0 4-Nitrophenacyl bromide 
• 5381-78-2 1-methyl-5-nitro-1H-benzo[d]imidazole 
• 82040-15-1 3-Methyl-6-nitro-1-[2-(4-nitro-phenyl)-2-oxo-ethyl]-3H-benzoimidazol-1-ium; bromide 

Relevant academic research and scientific papers

2-(4-ARYL-1H-IMIDAZOL-1-YL)ANILINE COMPOUNDS

The present invention provides compounds that are useful as vaccine adjuvants and/or antitumor agents and methods for producing and using the same. In one particular aspect of the invention, compounds of the invention are of the formula (I) where R1, R2, R3 and Ar1 are those defined herein.

Unusual cleavage of phenacyl-substituted benzimidazolium salts. Synthesis of 1,4-diarylimidazoles

The action of ammonium acetate in acetic acid on 1-alkyl(aralkyl)-3-phenacylbenzimidazolium bromides leads, in addition to the formation of a new imidazole ring, to cleavage of the benzimidazole fragment of the molecule at the 1,2 bond to give 1-alkyl(aralkyl)aminoaryl-4-arylimidazoles. 1,2-Dimethyl-3-(p-nitrophenacyl)benzimidazolium bromide is converted under similar conditions to the corresponding 2-methylimidazole. 4,4′-Dimethyl-2,2′-bis(p-nitrophenyl)-1,1′-dipyrrolo[1,2-a]benzimidazole was isolated as a side product of this reaction.