82045-55-4

Upstream product

• 114125-41-6 4-formyl-1-methoxy-2-methyl-5-(4-phenylsulphonylbut-2-en-2-yl)benzene 
• 114092-28-3 Acetic acid 2-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-ethyl ester 
• 101906-20-1 (2S,4S,6S,8R,9S)-4-(dimethyl-t-butylsiloxy)-8,9-dimethyl-2-<(2E)-3-phenylsulphonylbut-2-enyl>-1,7-dioxaspiro<5.5>undecane 
• 114125-40-5 2-{(1E,7E)-(R)-3-Benzenesulfonyl-4-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester 
• 10413-11-3 (5S,6R)-tetrahydro-5,6-dimethyl-2H-pyran-2-ol 
• 101978-61-4 (3R)-5-methylhex-5-ene-1,3-diol 
• 114180-44-8 (3S)-5-methylhex-5-ene-1,3-diol 
• 101906-16-5 2-<(3S,4S)-4-hydroxy-3-methylpentyl>-1,3-dioxolane 
• 114092-36-3 2-<(3S,4R)-4-hydroxy-3-methylpentyl>-1,3-dioxolane 
• 114092-43-2 4-acetoxymethyl-1-(2-hydroxybut-3-en-2-yl)-1-methoxy-2-methylbenzene 
• 114092-33-0 2-{(1E,7E)-(R)-9-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4-methanesulfonyloxy-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester 
• 114092-31-8 (2S,4S,6S,8R,9S)-2-<(5R)-4-(dimethyl-t-butylsiloxy)>-2-<(5R,2E)-6-hydroxy-3,5-dimethylhex-2-enyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane 
• 82045-36-1 (2S,4S,6S,8R,9S)-4-(dimethyl-t-butylsiloxy)-2-<(5R,2E)-5-formyl-3-methylhex-2-enyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane 
• 101906-21-2 (2R,4R,6S,8R,9S)-2-<(5R)-(2E)-6-benzyloxy-3,5-dimethyl-hex-2-en-1-yl>-8,9-dimethyl-4-(dimethyl-t-butylsilyloxy)-1,7-dioxaspiro<5.5>undecane 

Downstream Products

• 82045-56-5 2-[(1E,3E,7E)-(R)-9-((2S,4R,6S,8S,9R)-4-Hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-1,5,7-trimethyl-nona-1,3,7-trienyl]-4-methoxy-5-methyl-benzoic acid methyl ester 
• 82045-56-5 2-[(1E,3E,7E)-(S)-9-((2S,4R,6S,8S,9R)-4-Hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-1,5,7-trimethyl-nona-1,3,7-trienyl]-4-methoxy-5-methyl-benzoic acid methyl ester 
• 82045-56-5 2-[(1E,3E,7E)-(R)-9-((2R,4S,6R,8R,9S)-4-Hydroxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-1,5,7-trimethyl-nona-1,3,7-trienyl]-4-methoxy-5-methyl-benzoic acid methyl ester 

Relevant academic research and scientific papers

A Directed Aldol Approach to (+)-Milbemycin β3

Key steps in a total synthesis of (+)-milbemycin β3 are the construction of the 1,7-dioxaspiroundecane (10) by a Lewis acid-catalysed intramolecular directed aldol reaction and the use of sulphone-based olefination reactions for the constr

A Synthesis of (+)-Milbemycin β3. The Directed Aldol Approach

A synthesis of (+)-milbemycin β3, is reported in which key steps are the construction of the 1,7-dioxaspiroundecane (15) by a Lewis acid-catalysed intramolecular directed aldol reaction and the use of sulphone-based olefination reactions f