82053-19-8Relevant academic research and scientific papers
Decarboxylative N-Alkylation of Azoles through Visible-Light-Mediated Organophotoredox Catalysis
Kobayashi, Rino,Shibutani, Shotaro,Nagao, Kazunori,Ikeda, Zenichi,Wang, Junsi,Ibá?ez, Ignacio,Reynolds, Matthew,Sasaki, Yusuke,Ohmiya, Hirohisa
, p. 5415 - 5419 (2021)
An organophotoredox-catalyzed decarboxylative cross-coupling between azole nucleophiles and aliphatic carboxylic acid-derived redox-active esters is demonstrated. This protocol efficiently installs various tertiary or secondary alkyl fragments onto the nitrogen atom of azole nucleophiles under mild and transition-metal-free conditions. The pyridinium additive successfully inhibits the formation of elimination byproducts from the carbocation intermediate. This reaction is applicable to the synthesis of a protein-degrader-like molecule containing an azole and a thalidomide.
Syn-selective kobayashi aldol reaction using acetals
Tsukada, Hiroyuki,Mukaeda, Yuki,Hosokawa, Seijiro
supporting information, p. 678 - 681 (2013/04/10)
The Kobayashi aldol reaction has been used to construct anti-aldol products by remote stereoinduction. Since the product of the Kobayashi aldol reaction has a typical polyketide structure, this reaction has been applied to the total synthesis of natural p
