82056-47-1Relevant academic research and scientific papers
Studies on Organic Fluorine Compounds. 38. Ring-Opening Reactions of gem-Difluorocyclopropyl Ketones with Nucleophiles
Kobayashi, Yoshiro,Taguchi, Takeo,Morikawa, Tsutomu,Takase, Toyohiko,Takanashi, Hiroshi
, p. 3232 - 3236 (1982)
Syntheses of gem-difluorocyclopropyl ketones (3a-d) and their reactions with nucleophiles are described.Ring-opening reaction of 3a,c,d having a hydrogen substituent at C1 adjacent to the carbonyl group with a methanolate anion gave carboxylic acid derivatives derived from C1-C2 bond scission (between the carbon atom with an acyl group and the carbon atom with fluorine substituents).On the other hand, reaction of 3a-c with a thiolate anion resulted in the C1-C3 bond cleavage (carbon-carbon bond opposite to the difluoromethylene group).
