Welcome to LookChem.com Sign In|Join Free

CAS

  • or

82058-16-0

Post Buying Request

82058-16-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

82058-16-0 Usage

Description

NSC-33994 (82058-16-0) is a remarkably potent and selective JAK2 inhibitor (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.1?Suppresses JAK2-V617F-mediated human pathological cell growth?in vitro?and?in vivo2?and is concomitant with the disruption of intracellular vimentin filaments3. NSC-33994 reduces the tumorigenic potential of T98G glioblastoma cells?in vitro?and?in vivo.4

Uses

NSC-33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies.

References

1) Kiss?et al. (2009),?Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening; Bioorg. Med. Chem. Lett.,?19?3598 2) Kirabo?et al. (2011),?The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo; J. Biol. Chem.,?286?4280 3) Majumder?et al. (2011),?Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments; Biochemistry,?50?7774 4) Baskin?et al. (2014),?The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo; PLoS One,?9(8)?e105568

Check Digit Verification of cas no

The CAS Registry Mumber 82058-16-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,0,5 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 82058-16:
(7*8)+(6*2)+(5*0)+(4*5)+(3*8)+(2*1)+(1*6)=120
120 % 10 = 0
So 82058-16-0 is a valid CAS Registry Number.

82058-16-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Sigma

  • (SML0069)  NSC 33994  ≥98% (HPLC)

  • 82058-16-0

  • SML0069-5MG

  • 1,062.36CNY

  • Detail
  • Sigma

  • (SML0069)  NSC 33994  ≥98% (HPLC)

  • 82058-16-0

  • SML0069-25MG

  • 4,288.05CNY

  • Detail

82058-16-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(diethylaminomethyl)-4-[(E)-4-[3-(diethylaminomethyl)-4-hydroxyphenyl]hex-3-en-3-yl]phenol

1.2 Other means of identification

Product number -
Other names 4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylamino)methyl]phenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:82058-16-0 SDS

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 82058-16-0