82058-16-0 Usage
Uses
Used in Pharmaceutical Industry:
NSC 33994 is used as a novel inhibitor of JAK2 tyrosine kinase for the treatment of myeloproliferative disorders and hematological malignancies. Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of these diseases, and the inhibition of JAK2 by NSC 33994 can help in controlling their progression and improving patient outcomes.
References
1) Kiss?et al. (2009),?Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening; Bioorg. Med. Chem. Lett.,?19?3598
2) Kirabo?et al. (2011),?The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo; J. Biol. Chem.,?286?4280
3) Majumder?et al. (2011),?Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments; Biochemistry,?50?7774
4) Baskin?et al. (2014),?The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo; PLoS One,?9(8)?e105568
Check Digit Verification of cas no
The CAS Registry Mumber 82058-16-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,0,5 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 82058-16:
(7*8)+(6*2)+(5*0)+(4*5)+(3*8)+(2*1)+(1*6)=120
120 % 10 = 0
So 82058-16-0 is a valid CAS Registry Number.
