82064-77-5

Upstream product

• 252567-49-0 ethyl 2-O-BOC-6-ethylsalicylate 
• 1576-86-9 2-pentenal 
• 141-97-9 ethyl acetoacetate 
• 6555-40-4 ethyl 2-hydroxy-6-methylbenzoate 
• 252567-48-9 ethyl 2-O-BOC-6-methylsalicylate 
• 1629-58-9 4-penten-3-one 
• 57830-23-6 1-(3-Ethoxycarbonyl-2-oxopropyl)pyridinium bromide 
• 31199-03-8 1,1-dimethoxypentan-3-one 
• 89186-81-2 1-ethoxy-1,3-bis[(trimethylsilyl)oxy]buta-1,3-diene 
• 123-73-9 trans-Crotonaldehyde 
• 4949-44-4 ethyl propanoylacetate 
• 496-64-0 3-hydroxy-2-pyrone 
• 52194-37-3 ethyl 3-nitropent-2-enoate 

Downstream Products

• 186670-45-1 2-ethyl-6-methoxybenzoic acid ethyl ester 
• 1146962-12-0 C₁₃H₁₈O₄ 
• 66389-39-7 (+/-)-panacene 
• 252567-45-6 3-(2-ethyl-6-hydroxy-phenyl)-3-oxo-propionic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of Highly Substituted Phenols and Benzenes with Complete Regiochemical Control

Substituted phenols are requisite molecules for human health, agriculture, and diverse synthetic materials. We report a chemical synthesis of phenols, including penta-substituted phenols, that accommodates programmable substitution at any position. This method uses a one-step conversion of readily available hydroxypyrone and nitroalkene starting materials to give phenols with complete regiochemical control and in high chemical yield. Additionally, the phenols can be converted into highly and even fully substituted benzenes.

IMIDAZO 1, 2-A PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS DIABETES

Novel compounds of the formula (I), in which W, T, R1, R2, R3, R4, R5, R6 and X7 have the meanings indicated in Patent Claim 1, are suitable as antidiabetics.

Synthesis of functionalized salicylates by formal [3+3] cyclocondensation of 1,3-bis(silyloxy)buta-1,3-dienes with 3-alkoxy-2-en-1-ones

The formal [3+3] cyclization of 1,3-bis(silyloxy)buta-1,3-dienes with 1-aryl-3-ethoxyprop-2-en-1-ones, available by Heck reaction of benzoyl chlorides with ethyl vinyl ether, afforded a variety of 6-arylsalicylates. The reaction of the products with conce

Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications

The potent antiproliferative agent SDZ LAP 977, which has shown efficacy in a clinical proof of concept study in actinic keratosis patients, has been previously demonstrated to block the cell cycle in mitosis. In the present study, we further explored the mode of action: SDZ LAP 977 binds to the "colchicine binding site" on tubulin and, thus, inhibits tubulin polymerization in vitro. Moreover, we established structure-activity relationships for the effect of modifications in the 2,5-dimethoxyphenyl moiety ("ring A") of the molecule on in vitro antiproliferative activity.

A straightforward entry into polyketide monoprenylated furanocoumarins and pyranocoumarins

A regioselective synthesis of 5-methyl- and 5-ethyl-4- hydroxycoumarin (1b and 1c, respectively) is described. Starting from these compounds, several prenylated polyketide coumarins of limited availability from natural sources and important taxonomic relevance were prepared.