31199-03-8

Basic information

• Product Name: 3-Pentanone, 1,1-dimethoxy-
• Synonyms: 3-Oxo-valeraldehyd-dimethylacetal;1,1-Dimethoxypentan-3-on;1,1-dimethoxy-pentan-3-one;3-oxo-valeraldehyde dimethylacetal;1,1-dimethoxy-3-pentanone;pentan-3-one-1-al dimethylacetal;3-Pentanone,1,1-dimethoxy
• CAS NO: 31199-03-8
• Molecular Formula: C7H14O3
• Molecular Weight: 146.186
• Mol File: 31199-03-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-Pentanone, 1,1-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pentanone, 1,1-dimethoxy-(31199-03-8)
• EPA Substance Registry System: 3-Pentanone, 1,1-dimethoxy-(31199-03-8)

Safety Data

• Hazardous Substances Data: 31199-03-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 18387-58-1 1-(trimethylsilyl)-1-pentyne-3-one 
• 593-60-2 Vinyl bromide 
• 124-41-4 sodium methylate 
• 79-03-8 propionyl chloride 
• 6651-40-7 2-(trimethylsilyloxy)-1-butene 
• 149-73-5 trimethyl orthoformate 
• 56699-03-7 1-methoxy-3-methylsulfanyl-penta-1,2-diene 
• 14674-62-5 1-methoxy-pent-1-en-3-yne 
• 107-31-3 Methyl formate 
• 78-93-3 butanone 
• 58953-12-1 (E)-1-chloropent-1-en-3-one 

Downstream Products

• 14269-18-2 3-ethyl-1-(4-nitro-phenyl)-1H-pyrazole 
• 14269-17-1 5-ethyl-1-(4-nitro-phenyl)-1H-pyrazole 
• 1576-87-0 trans-2-pentenal 
• 939-27-5 2-ethylnaphthalene 
• 71539-38-3 4-ethyl-2-hydroxybenzoic acid ethyl ester 
• 82064-77-5 2-ethyl-6-hydroxybenzoic acid ethyl ester 
• 1189819-97-3 (2-ethyl-6-hydroxyphenyl)phenylmethanone 
• 78473-50-4 4-Aethyl-2-hydroxy-benzophenon 
• 1189819-99-5 C₁₂H₁₆O₂ 
• 1189819-98-4 1-(6-ethyl-2-hydroxy-3-methylphenyl)propan-1-one 
• 5896-50-4 1-(4-ethyl-2-hydroxyphenyl)-ethanone 
• 704913-86-0 tert-butyl (3-ethyl-furan-2-yl)carbamate 
• 704913-84-8 3-ethyl-furan-2-carboxylic acid methyl ester 
• 934340-49-5 C₁₅H₁₅ClO₄ 

Relevant articles and documents

Catalytic asymmetric hydrogenation of pyrimidines

The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]2, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)3 (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.

PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS

The invention relates to pyrimidin-2-one compounds of general formula (I), in addition to the derivatives and tautomers of (I) and the physiologically acceptable salts of said compounds. In said formula: A represents linear or branched C3-C6 alkene, which can have a double bond or triple bond and/or a group Z, which is not adjacent to the nitrogen atom of the pyrimidinone ring and is selected from O, S, C(O), NR3, C(O)NR3, NR3C(O), OC(O) and C(O)O; B represents a group of formula (II), in which X stands for CH2 or N and Y stands for CH2 or CH2CH2, or X-Y can also jointly represent C=CH, C=CH-CH2 or CH-CH=CH; R1 and R 2 are defined as cited in the description and the claims; and Ar represents an optionally substituted aromatic group. The invention also relates to a pharmaceutical agent, containing at least one compound (I) and the tautomers, derivatives and/or acid addition salts of said compound, optionally together with physiologically acceptable carriers and/or auxiliary agents. The invention also relates to the use of compounds of formula (I), and their tautomers, derivatives and pharmacologically acceptable acid addition salts for producing a pharmaceutical agent for treating diseases, which respond to the influence of dopamine D3 receptor ligands.

Stereospecific synthesis of cryptophycin 1

Matrix presented A brief stereospecific synthesis of cryptophycin 1 is described in which (R)-mandelic acid serves as the sole source of asymmetry for unit A. The key step is a hetero-Diels-Alder cycloaddition.