82079-44-5Relevant academic research and scientific papers
D-β-Chlorolactic Acid: A Chemical Synthesis
Morin, Christophe,Sawaya, George
, p. 479 - 480 (1987)
Nitrous deamination of serine-derived β-chloroalanine proceeds without significant racemization, thus opening a chemical route to optically active β-chlorolactic acid.
CARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS
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Page/Page column 34-35, (2008/06/13)
The invention relates to the novel compounds of formula (I), wherein R1, D, X, W, Y and T are defined as in claim 1, for example (II). The novel compounds inhibit coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.
Novel chemo-enzymatic synthesis of optically active platelet activating factor
Kumar,Bhakuni
, p. 3463 - 3466 (2007/10/02)
This paper describes an enantioselective enzymatic synthesis of biologically active platelet activating factor (PAF) starting from chloropyruvic acid.
Enzymatic Synthesis of Optically Pure (R)-(-)-Mandelic Acid and Other 2-Hydroxycarboxylic Acids: Screening for the Enzyme, and Its Purification, Characterization and Use
Yamazaki, Yoshimitsu,Maeda, Hidekatsu
, p. 2621 - 2632 (2007/10/02)
An enzyme that reduces benzoylformate with NADH to form (R)-mandelate was extracted from cells of Streptococcus faecalis IFO 12964 and purified to more than 95percent purity as evidenced by gel electrophoresis.Physicochemical and enzymic properties were studied.From the substrate specificity, we concluded that the enzyme was a kind of (R)-2-hydroxyisocaproate dehydrogenase.Optically pure (R)-(-)-mandelic acid was prepared with the enzyme, NADH, and alcohol, formate or glucose dehydrogenase in 84 ca. 93percent yield.Five (R)-2-hydroxyalkanoic acids (C4 - C6) or their Ba salts, (R)-(+)-3-phenyllactic acid and (S)-(-)-3-chlorolactic acid were also prepared with the enzyme.
Laboratory-Scale Enzymatic/Chemical Syntheses of D- and L-β-Chlorolactic Acid and D- and L-Potassium Glycidate
Hirschbein, Bernard L.,Whitesides, George M.
, p. 4458 - 4460 (2007/10/02)
This paper describes preparations of D- (and L-) chlorolactic acids having enantiomeric excesses greater than 97percent by D- (and L-) lactate dehydrogenase catalyzed reduction of chloropyruvic acid with NADH.In syntheses carried out on 0.1-0.5 mol scales
