82082-44-8Relevant articles and documents
Potential Central Nervous System Active Agents. 1. Synthesis of N-Benzylphenylacetamides
Agwada, Vincent C.
, p. 481 - 483 (1982)
Six N-benzylphenylacetamides variously substituted on the acyl part with chloro, methyl, or methoxyl groups, including five new ones, were synthesized by heating their corresponding N-benzylammonium salts in o-xylene.Their IR, NMR, and mass-spectral (MS) data are presented and compared with those of the N-benzylbenzamides and N-benzylacetamide, respectively.
Direct amidation of non-activated carboxylic acid and amine derivatives catalyzed by TiCp2Cl2
Wang, Hui,Dong, Wei,Hou, Zhipeng,Cheng, Lidan,Li, Xiufen,Huang, Longjiang
, (2020/02/15)
This paper described a mild and efficient direct amidation of non-activated carboxylic acid and amine derivatives catalyzed by TiCp2Cl2. Arylacetic acid derivatives reacted with different amines to afford the corresponding amides in good to excellent yield except of aniline. Aryl formic acids failed to react with aniline but smoothly reacted with aliphatic amines and benzylamine in moderate to good yield, fatty acids reacting with benzyl and aliphatic amines give amides in good to excellent yield. Chiral amino acids derivatives were transformed into amides without racemization in moderate yield. The possible mechanism of direct amidation catalyzed by TiCp2Cl2 was discussed. This catalytic method is very suitable for the amidation of low sterically hindered arylacetic acid, fatty acids with different low sterically hindered amines except aniline, as well as the amidation of aryl formic acid with benzyl and aliphatic amines.
Microwave specific Wolff rearrangement of α-diazoketones and its relevance to the nonthermal and thermal effect
Sudrik, Surendra G.,Chavan, Sambhaji P.,Chandrakumar,Pal, Sourav,Date, Sadgopal K.,Chavan, Subhash P.,Sonawane, Harikisan R.
, p. 1574 - 1579 (2007/10/03)
α-Diazoketones possess high electric dipole moments, as a consequence of the dipolar nature of the diazocarbonyl functional group. The vectorial analysis, theoretical calculations (PM3 and ab initio), and literature reports based on experimental and theor
