41441-74-1

Upstream product

• 577-16-2 2-Methylacetophenone 
• 118-90-1 ortho-methylbenzoic acid 
• 847500-51-0 1,3-bis(2-methylphenyl)propan-1,3-dione 
• 186581-53-3 diazomethane 
• 933-88-0 ortho-toluoyl chloride 
• 163266-02-2 4,4,4-trifluoro-1-(2-methylphenyl)butane-1,3-dione 

Downstream Products

• 4209-23-8 2-chloro-1-(o-tolyl)ethan-1-one 
• 195137-30-5 1-(2-methylphenyl)pentane-1,4-dione 
• 1127405-02-0 1-morpholino-2-(o-tolyl)ethane-1,2-dione 
• 137600-14-7 2-oxo-2-(o-tolyl)acetamide 
• 82082-44-8 N-benzyl-2-(2-methylphenyl)acetamide 
• 83-33-0 inden-1-one 

Relevant academic research and scientific papers

A Sequential Route to Cyclopentenes from 1,6-Enynes and Diazo Ketones through Gold and Rhodium Catalysis

This work reports the construction of cyclopentene cores from 1,6-enynes and aryl diazo ketones through two new reaction sequences involving initial gold-catalyzed cyclization of 1,6-enynes with diazo species, followed by rhodium-catalyzed skeletal rearrangement of the resulting 3-cyclopropyl-2-en-1-ones. In most instances the rhodium-catalyzed reactions afforded cyclopentene derivatives whereas several n-alkyl- or ortho-substituted phenyl ketones delivered seven-membered oxacycles. A plausible mechanism provides rationales for these two distinct products. (Figure presented.).

Tandem Synthesis of α-Diazoketones from 1,3-Diketones

A highly efficient synthesis of α-diazoketone was achieved by simply stirring the mixture of 1,3-diketone, TsN3, and MeNH2 in EtOH. It was a tandem reaction including a novel primary amine-catalyzed Regitz diazo transfer of 1,3-diket

Potent and subtype-selective CCK-B/gastrin receptor antagonists: 2,4-dioxo-1,5-benzodiazepines with a plane of symmetry

A series of CCK-B/gastrin receptor antagonists, 2,4-dioxo-1,5-benzodiazepine derivatives with a plane of symmetry, were designed, synthesized, and evaluated for antagonistic activity. Structure-activity relationship studies revealed that carbonylmethyl groups at both N-1 and N-5 positions and hydrophilic groups, such as the carboxyl group on the benzene ring attached to the ureido group at the C-3 position, brought about potent affinity and subtype selectivity for CCK-B/gastrin receptors. Several compounds showed excellent in vivo inhibition of gastric acid secretion induced by pentagastrin in anesthetized rats.

A New, General Cyclopentenone Synthesis

A new synthesis of cyclopentenones, involving an Rh(II)-catalyzed, intramolecular carbon-hydrogen insertion of diazomethyl ketones derived from α,β-unsaturated acids, is described.