82085-61-8Relevant academic research and scientific papers
SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES
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Page/Page column 72, (2010/02/15)
The invention relates to substituted acids of formula (I), where T,W,X,Y,Z, R1 and R2 as defined in the claims, as useful pharmaceutical compounds for treating asthma and rhinitis, pharmaceutical compositions containing them, and a processes for their preparation.
Preparation process for hydroxyphenylacetic acids
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, (2008/06/13)
Preparation process for a hydroxyphenylacetic acid of formula (I): STR1 where R=H, alkyl or alkoxyl as well as its salts, in which the corresponding free or salified hydroxymandelic acid of formula (II): STR2 in which R has the meaning given previously and M=H, K or an ammonium group is reacted in an aqueous medium, at a temperature greater than or equal to 50° C., with formic acid in the presence of catalytic quantities of an oxygenated derivative of sulphur having a degree of oxidation from 2 to 4, in order to obtain the hydroxyphenylacetic acid of formula (I) which is isolated or, if desired, is salified according to the usual methods and the hydroxyphenylacetic acid thus obtained.
