82087-73-8 Usage
Uses
Used in Medicinal Chemistry:
(2S,4S)-4-Benzyl-pyrrolidine-2-carboxylic acid is used as a building block in medicinal chemistry for its ability to interact with biological systems and modify their activity. Its unique structure allows it to be incorporated into various drug molecules, potentially enhancing their efficacy and selectivity.
Used in Drug Development:
In drug development, (2S,4S)-4-benzyl-pyrrolidine-2-carboxylic acid serves as a key intermediate in the synthesis of pharmaceutical compounds. Its presence in drug molecules can contribute to improved pharmacokinetic and pharmacodynamic properties, such as increased solubility, stability, and bioavailability.
Used in Organic Synthesis:
(2S,4S)-4-Benzyl-pyrrolidine-2-carboxylic acid is utilized as a versatile synthetic building block in the preparation of other organic compounds with specific structural and functional properties. Its reactivity and compatibility with various synthetic methods make it a valuable component in the synthesis of complex organic molecules, including natural products, agrochemicals, and specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 82087-73-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,0,8 and 7 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 82087-73:
(7*8)+(6*2)+(5*0)+(4*8)+(3*7)+(2*7)+(1*3)=138
138 % 10 = 8
So 82087-73-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H15NO2/c14-12(15)11-7-10(8-13-11)6-9-4-2-1-3-5-9/h1-5,10-11,13H,6-8H2,(H,14,15)/t10-,11-/m0/s1
82087-73-8Relevant academic research and scientific papers
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines
Krapcho,Turk,Cushman,Powell,DeForrest,Spitzmiller,Karanewsky,Duggan,Rovnvak,Schwartz,Natarajan,Godfrey,Ryono,Neubeck,Atwa,Petrillo Jr.
, p. 1148 - 1160 (2007/10/02)
Analogues of captopril, enalaprilat, and the phosphinic acid [[hydroxy(4-phenylbutyl)phosphinyl]acetyl)-L-proline incorporating 4-substituted proline derivatives have been synthesized and evaluated as inhibitors of angiotensin-converting enzyme (ACE) in vitro and in vivo. The 4-substituted prolines, incorporating alkyl, aryl, alkoxy, aryloxy, alkylthio, and arylthio substituents were prepared from derivatives of 4-hydroxy- and 4-ketoproline. In general, analogues of all three classes of inhibitors with hydrophobic substituents on proline were more potent in vitro than the corresponding unsubstituted proline compounds. 4-Substituted analogues of captopril showed greater potency and duration of action than the parent compound as inhibitors of the angiotensin I induced pressor response in normotensive rats. The S-benzoyl derivative of cis-4-(phenylthio)captopril, zofenopril, was found to be one of the most potent compounds of this class and is now being evaluated clinically as an antihypertensive agent. In the phosphinic acid series, the 4-ethylenethioketal and trans-4-cyclohexyl derivatives were found to be the most potent compounds in vitro and in vivo. A prodrug of the latter compound, fosinopril, is also being evaluated in clinical trials.
