82102-21-4Relevant academic research and scientific papers
A β - hydroxyalkanephosphonic ester derivatives
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Paragraph 0126; 0131, (2017/08/31)
The invention discloses a preparation method of beta-hydroxyphosphonate derivatives. The preparation method comprises that an arylethene derivative, a phosphorus reagent and manganese acetate are dissolved in a solvent and the solution undergoes a reactio
Potential GABAB receptor antagonists. IX: The synthesis of 3-amino-3-(4-chlorophenyl)propanoic acid, 2-amino-2-(4-chlorophenyl)ethylphosphonic acid and 2-amino-2-(4-chlorophenyl)ethanesulfonic acid
Abbenante, Giovanni,Hughes, Robert,Prager, Rolf H.
, p. 523 - 527 (2007/10/03)
This paper describes the synthesis of 3-amino-3-(4-chlorophenyl)propanoic acid and the corresponding phosphonic and sulfonic acids, lower homologues of baclofen, phaclofen and saclofen respectively. The chlorinated acids were all weak specific antagonists of GABA at the GABAB receptor, with the sulfonic acid (pA2 4·0) being stronger than the phosphonic acid (pA2 3·8) and carboxylic acid (pA2 3·5).
ORGANIC PHOSPHORUS COMPOUNDS 105 SYNTHESIS AND PROPERTIES OF 2-AMINO-2-ARYLETHYLPHOSPHONIC ACIDS AND DERIVATIVES
Maier, Ludwig,Diel, Peter J.
, p. 245 - 256 (2007/10/03)
2-Amino-2-arylethylphosphonic acids, 6a to 6q have been prepared from the corresponding 2-acetoxyimino- or 2-methoxyimino-2-aryl-ethylphosphonates, 3 or 4, by hydrogenation using Raney-Ni as a catalyst, followed by hydrolysis with HCl. 3 and 4 were obtain
ANIMATION REDUCTRICE DES β-CETOPHOSPHONATES: PREPARATION D'ACIDES AMINOALKYLPHOSPHONIQUES
Varlet, J. M.,Collignon, N.,Savignac, Ph.
, p. 3713 - 3721 (2007/10/02)
Diethyl 2-oxo-alkylphosphonates undergo reductive amination in the presence of an amine and sodium cyanohydridoborate (NaBH3CN) in MeOH at Ph 7-7.5.Studies with a large variety of ketophosphonates show that the reaction rate is very sensitive to steric hi
