82102-48-5

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 25412-56-0 1-o-Tolyl-propane-1,2-dione 

Downstream Products

• 85616-29-1 2-aminothiazol-4-yl 2-o-methylphenyl ketone 
• 749846-46-6 [2-(3-amino-propylamino)-thiazol-4-yl]-o-tolyl-methanone 
• 593269-10-4 {3-[4-(2-Methyl-benzoyl)-thiazol-2-ylamino]-propyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

THIAZOLE DERIVATIVES

Compounds of formula I are provided as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5, n, m and A have the significance disclosed in the specification, and can be used for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.

Preparation and Photocyclisation of Bromomethyl 1,2-Diketones

A simple preparative route to the title compounds is given involving bromine addition to α-ethoxyvinyl ketones and subsequent hydrolysis.These compounds undergo efficient photocyclisation with retention of the halogen to hydroxycyclobutanone and hydroxycy