25412-56-0

Upstream product

• 79-20-9 acetic acid methyl ester 
• 201230-82-2 carbon monoxide 
• 6699-93-0 (2-methylphenyl)lithium 
• 14918-24-2 β-methyl-3-methylstyrene 
• 2040-14-4 2-methylpropiophenone 
• 51052-00-7 1-(2-methylphenyl)acetone 
• 615-37-2 ortho-methylphenyl iodide 
• 119072-55-8 tert-butylisonitrile 
• 75-24-1 trimethylaluminum 
• 95-46-5 2-methylphenyl bromide 
• 75205-42-4 1-(o-methylphenyl)-1-cyanoacetone 
• 1346260-43-2 (E)-2-(methoxyimino)-1-o-tolylpropan-1-one 
• 1451-84-9 2-Bromo-1-o-tolyl-propan-1-one 
• 933-88-0 ortho-toluoyl chloride 

Downstream Products

• 82102-48-5 3-bromo-1-o-methylphenylpropane-1,2-dione 

Relevant academic research and scientific papers

Palladium-Catalyzed Synthesis of 1,2-Diketones from Aryl Halides and Organoaluminum Reagents Using tert-Butyl Isocyanide as the CO Source

In this work, an interesting and practical procedure for the synthesis of 1,2-diketones from aryl halides and organoaluminum reagents has been developed. Employing tert-butyl isocyanide as the CO source and palladium as the catalyst, the desired 1,2-diketones were isolated in good to excellent yields with good functional group tolerance. Concerning the reaction partners, besides aryl halides, both alkyl- A nd arylaluminum reagents were all suitable substrates here.

Synthesis of 1,2-diketones from β-keto nitriles via a protection-oxidative-decyanation-deprotection protocol

A variety of 1,2-diketones were prepared from -keto nitriles via a three-step protocol including the protection of the ketones with methoxyamine, oxidative decyanation, and microwave-assisted deprotection in the final step. This approach provides a novel and efficient access to a wide scope of symmetric and unsymmetric 1,2-diketones using molecular oxygen as the oxidant in the decyanation process. Georg Thieme Verlag Stuttgart - New York.

THIAZOLE DERIVATIVES

Compounds of formula I are provided as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5, n, m and A have the significance disclosed in the specification, and can be used for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.

Asymmetric reduction of α-keto esters and α-diketones with a bakers' yeast keto ester reductase

Optically pure α-hydroxy esters and α-hydroxy ketones have been synthesized by the reduction of the corresponding ketones with a keto ester reductase isolated from bakers' yeast (YKER-I). The reduction of α-keto esters affords the corresponding (S)- or (R)-hydroxy esters selectively, where the stereochemical course depends on the chain length of the alkyl substituent on the carbonyl group. An α-keto short alkanoic ester affords the corresponding (S)-hydroxy ester, whereas a long alkanoate yields the corresponding (R)-hydroxy ester. The reduction of α-diketones affords the corresponding (S)-2-hydroxy ketones regio- and stereoselectively.