82102-84-9Relevant academic research and scientific papers
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs
Guandalini,Martini,Di Cesare Mannelli,Dei,Manetti,Scapecchi,Teodori,Ghelardini,Romanelli
supporting information; experimental part, p. 1936 - 1939 (2012/04/04)
A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds.
