82111-96-4Relevant academic research and scientific papers
Regiospecific Synthesis of Sarkomycin and Some Analogues
Marx, John N.,Minaskanian, Gevork
, p. 3306 - 3310 (1982)
The first regiospecific total synthesis of the anticancer compound sarkomycin (1) is described.The starting material is 2-(carbomethoxycyclopent-2-enone (4), a useful precursor for cyclopentanoid natural products.The cyano derivative 5, the amide derivative 6, and the keto lactone 9 were also synthetized.The latter may be considered as a "cyclized" form of sarkomycin and was shown to open slowly to the natural product upon treament with dilute acid.
