Journal of Organic Chemistry p. 3306 - 3310 (1982)
Update date:2022-08-03
Topics:
Marx, John N.
Minaskanian, Gevork
The first regiospecific total synthesis of the anticancer compound sarkomycin (1) is described.The starting material is 2-(carbomethoxycyclopent-2-enone (4), a useful precursor for cyclopentanoid natural products.The cyano derivative 5, the amide derivative 6, and the keto lactone 9 were also synthetized.The latter may be considered as a "cyclized" form of sarkomycin and was shown to open slowly to the natural product upon treament with dilute acid.
View MoreZhejiang Chemline International Co., Ltd.
Contact:+86-571-88062298
Address:Hengdian Industry Area, Dongyang, Zhejiang, China
ZhangJiaGang YaRui Chemical Co.,Ltd.
Contact:0512-58360968
Address:China JiangSu Province Zhang Jia Gang City YangShe Oriental Plaza Building 10 B307
Triumph International Development Limilted
website:http://www.jiashengchem.cn/
Contact:+86-536-7971999
Address:Yinhai Road,Shouguang
website:http://www.antaibio.com
Contact:0086-21-65663057
Address:Room 2108, Building 2，No. 489 Zhengli Road，200433
Shanghai HengXun Pharmaceutical Tech. Co., Ltd.
Contact:86-86-52730756
Address:Room 603, No. 240, Tianmuzhong Road, Zhabei, Shanghai, China
Doi:10.1007/s12039-017-1223-4
(2017)Doi:10.1021/ja00384a071
(1982)Doi:10.1021/ja00380a040
(1982)Doi:10.1021/ol048161l
(2004)Doi:10.1021/jo00176a002
(1984)Doi:10.1016/S0040-4039(00)87103-8
(1982)
