Journal of Organic Chemistry p. 3306 - 3310 (1982)
Update date:2022-08-03
Topics:
Marx, John N.
Minaskanian, Gevork
The first regiospecific total synthesis of the anticancer compound sarkomycin (1) is described.The starting material is 2-(carbomethoxycyclopent-2-enone (4), a useful precursor for cyclopentanoid natural products.The cyano derivative 5, the amide derivative 6, and the keto lactone 9 were also synthetized.The latter may be considered as a "cyclized" form of sarkomycin and was shown to open slowly to the natural product upon treament with dilute acid.
View MoreYingYing Pharmaceutical Co.,Ltd
Contact:86-18854126208
Address:55#, yingxiongshan road
Contact:86-25-51817806
Address:No. 216, middle longpan road, jincheng tower, floor 21-22, nanjing ,china
PINGYUAN SIHUAN PHARMACEUTICAL CO., LTD
Contact:+86-531-55696072
Address:#2766,yinxiu Road, Economic Development Zone, Pingyuan Country, Shandong Province, China.
VanderArk International Limited
Contact:86-10-82437576
Address:Qing He
website:http://www.tbbmed.com
Contact:86--21-50498136
Address:Room 6002, Building 7-1, No.160 Basheng Road,Pudong Area,Shanghai China
Doi:10.1007/s12039-017-1223-4
(2017)Doi:10.1021/ja00384a071
(1982)Doi:10.1021/ja00380a040
(1982)Doi:10.1021/ol048161l
(2004)Doi:10.1021/jo00176a002
(1984)Doi:10.1016/S0040-4039(00)87103-8
(1982)
