Journal of Organic Chemistry p. 3306 - 3310 (1982)
Update date:2022-08-03
Topics:
Marx, John N.
Minaskanian, Gevork
The first regiospecific total synthesis of the anticancer compound sarkomycin (1) is described.The starting material is 2-(carbomethoxycyclopent-2-enone (4), a useful precursor for cyclopentanoid natural products.The cyano derivative 5, the amide derivative 6, and the keto lactone 9 were also synthetized.The latter may be considered as a "cyclized" form of sarkomycin and was shown to open slowly to the natural product upon treament with dilute acid.
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Doi:10.1007/s12039-017-1223-4
(2017)Doi:10.1021/ja00384a071
(1982)Doi:10.1021/ja00380a040
(1982)Doi:10.1021/ol048161l
(2004)Doi:10.1021/jo00176a002
(1984)Doi:10.1016/S0040-4039(00)87103-8
(1982)
