82126-34-9

Upstream product

• 10061-68-4 N,N'-diethyl-1,3-propanediamine 
• 98-88-4 benzoyl chloride 
• 10364-94-0 1-benzoylimidazole 
• 90001-92-6 N,N'-diethyl-propanediyldiamine; dihydrochloride 
• 4669-59-4 bis(diethylamino)dimethylsilane 
• 36929-94-9 1,3-diethyl-2,2-dimethyl-[1,3,2]diazasilinane 

Relevant academic research and scientific papers

Imidazole-catalyzed monoacylation of symmetrical diamines

Figure Presented. An imidazole-catalyzed protocol for monoacylation of symmetrical diamines has been developed. The protocol gave selective monoacylation of aliphatic (cyclic and acyclic) primary and secondary diamines. In the reaction, imidazole acts as both catalyst and a leaving group. Different monoacylated piperazines and other diamines were synthesized at room temperature in an ethanol/water solvent system.

Selective Monoacylation of Symmetrical Diamines via Prior Complexation with Boron

(Equation presented) Pretreatment of a symmetrical primary or secondary diamine with 9-BBN prior to the addition of an acyl chloride significantly suppressed undesired diacylation, and the product of monoacylation predominated. The reactive preference is interpreted as the result of a selective deactivation of one nitrogen atom of the diamine by 9-BBN.

SYNTHESIS WITH SILICON DERIVATIVES: NON SYMMETRICAL DERIVATIZATION OF SYMMETRICAL DIAMINES

The conversion of symmetrical diamines to monoamides via the use of cyclic siliconnitrogen compounds as intermediates is described.