82127-24-0

Upstream product

• 107-14-2 chloroacetonitrile 
• 82127-15-9 4-(4-chlorophenyl)-6-(thien-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 82127-20-6 (4-(p-chlorophenyl)-3-cyano-6-(2'-thienyl)-2-pyridinylthio)acetonitrile 
• 88-15-3 2-Acetylthiophene 
• 39145-33-0 2-cyano-3-(4-chlorophenyl)-prop-2-enethioamide 

Relevant academic research and scientific papers

Some reactions of 2-functionalized 3-amino-4-aryl-6-(2′-thienyl)-thieno[2,3-B]-pyridines: Synthesis of new pyridothienopyrimidines, pyridothienotriazines and related fused tetracyclic systems

4-Aryl-3-cyano-6-(2′-thienyl)-pyridine-2(1H)-thiones (2a-c) were prepared and reacted with chloroacetonitrile or chloroacetamide to furnish 3-amino-4-aryl-6-(2′-thienyl)-thieno[2,3-b]pyridine-2-carbonitriles (4a-c) and 2-carboxamide analogs 6a-c respectiv

CYCLIZATION REACTIONS OF NITRILES. 2-ARYL-3-(2-THENOYL)-1,1-DICYANOPROPANES AND PYRIDINE DERIVATIVES BASED ON THEM

In the reaction of 1,1,1-trifluoro-3-(2-thenoyl)acetone with arylidenemalononitriles acid cleavage of the products from Michael addition takes place with the formation of 2-aryl-3-(2-thenoyl)-1,1-dicyanopropanes.They were used for the synthesis of 4-aryl-2-bromo-6-(2-thienyl)-3-cyanopyridines and 4-aryl-6-(2-thienyl)-3-cyano-2(1H)-pyridinethiones and condensed heterocyclic compounds based on them.