82128-69-6

Upstream product

• 1996-41-4 2-chloro-4-fluorophenol 
• 67-66-3 chloroform 
• 50-00-0 formaldehyd 

Downstream Products

• 1226513-94-5 (4-fluorophenoxy)acetic acid (3-chloro-5-fluoro-2-hydroxybenzylidene)hydrazide 
• 1226513-95-6 3,5-dichlorobenzoic acid (3-chloro-5-fluoro-2-hydroxybenzylidene)hydrazide 
• 1374669-74-5 C₉H₇ClFNO₃ 
• 1374669-75-6 C₁₀H₉ClFNO₃ 

Relevant academic research and scientific papers

MACROCYCLE KINASE INHIBITORS

The present disclosure relates to certain macrocyclic kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same to treat disease.

IMIDAZOLE DERIVATIVES AS IDO INHIBITORS

Presently provided are IDO inhibitors of general formulae (VII), (VIII) as shown below and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.

6-(Poly-substituted aryl)-4-aminopicolinates and their use as herbicides

4-Aminopicolinic acids having tri- and tetra-substituted aryl substituents in the 6-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.

Hypoglycemic 5-substituted oxazolidine-2,4-diones

Hypoglycemic 5-phenyl and 5-naphthyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.