82137-59-5

Upstream product

• 79442-37-8 3-(4-chlorophenyl)-1-(thiophen-2-yl)prop-2-en-1-one 
• 109-77-3 malononitrile 
• 326-91-0 1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 

Downstream Products

• 1595291-84-1 4-(4-chlorophenyl)-2-(1-piperidinyl)-6-(2-thienyl)-3-pyridinecarbonitrile 
• 1595291-88-5 4-(4-chlorophenyl)-2-(4-morpholinyl)-6-(2-thienyl)-3-pyridinecarbonitrile 
• 1595291-92-1 4-(4-chlorophenyl)-2-[1-(4-methylpiperazinyl)]-6-(2-thienyl)-3-pyridinecarbonitrile 
• 1595291-94-3 4-(4-chlorophenyl)-2-[1-(4-ethylpiperazinyl)]-6-(2-thienyl)-3-pyridinecarbonitrile 
• 82127-15-9 4-(4-chlorophenyl)-6-(thien-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 82127-09-1 2-bromo-4-(4-chlorophenyl)-6-(2-thienyl)-3-pyridinecarbonitrile 
• 82127-16-0 4-(4-Chloro-phenyl)-6-thiophen-2-yl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile; compound with morpholine 

Relevant academic research and scientific papers

Synthesis, bioassay, and molecular field topology analysis of diverse vasodilatory heterocycles

A diverse training set composed of 76 in-house synthesized and 61 collected from the literature was subjected to molecular field topology analysis. This resulted in a high-quality quantitative structure-activity relationships model (R2 = 0.932,

CYCLIZATION REACTIONS OF NITRILES. 2-ARYL-3-(2-THENOYL)-1,1-DICYANOPROPANES AND PYRIDINE DERIVATIVES BASED ON THEM

In the reaction of 1,1,1-trifluoro-3-(2-thenoyl)acetone with arylidenemalononitriles acid cleavage of the products from Michael addition takes place with the formation of 2-aryl-3-(2-thenoyl)-1,1-dicyanopropanes.They were used for the synthesis of 4-aryl-2-bromo-6-(2-thienyl)-3-cyanopyridines and 4-aryl-6-(2-thienyl)-3-cyano-2(1H)-pyridinethiones and condensed heterocyclic compounds based on them.