3-(4-chlorophenyl-1-(2-thienyl)-3-oxopropyl)propanedinitrile

Base Information

• Chemical Name: 3-(4-chlorophenyl-1-(2-thienyl)-3-oxopropyl)propanedinitrile
• CAS No.: 82137-59-5
• Molecular Formula: C₁₆H₁₁ClN₂OS
• Molecular Weight: 314.795
• Mol file: 82137-59-5.mol

Synonyms:3-(4-chlorophenyl-1-(2-thienyl)-3-oxopropyl)propanedinitrile

Chemical Property of 3-(4-chlorophenyl-1-(2-thienyl)-3-oxopropyl)propanedinitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl-1-(2-thienyl)-3-oxopropyl)propanedinitrile

There total 2 articles about 3-(4-chlorophenyl-1-(2-thienyl)-3-oxopropyl)propanedinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-(4-chlorophenyl)-1-(thiophen-2-yl)prop-2-en-1-one (79442-37-8,6028-96-2) + malononitrile (109-77-3) → 3-(4-chlorophenyl-1-(2-thienyl)-3-oxopropyl)propanedinitrile (82137-59-5)

Guidance literature:

With morpholine; In ethanol; at 20 - 25 ℃; for 6h;

DOI:10.1021/ci400723m

Reference yield: 48.0%

1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione (326-91-0) + 4-chlorobenzylidenemalonodinitrile (1867-38-5) → 3-(4-chlorophenyl-1-(2-thienyl)-3-oxopropyl)propanedinitrile (82137-59-5)

Guidance literature:

With morpholine; In ethanol; for 2h; Heating;

Reference yield: 72.0%

3-(4-chlorophenyl-1-(2-thienyl)-3-oxopropyl)propanedinitrile (82137-59-5) → 2-bromo-4-(4-chlorophenyl)-6-(2-thienyl)-3-pyridinecarbonitrile (82127-09-1)

Guidance literature:

With bromine; acetic acid; at 60 - 70 ℃; for 3h;

DOI:10.1021/ci400723m

upstream raw materials:

1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione

4-chlorobenzylidenemalonodinitrile

3-(4-chlorophenyl)-1-(thiophen-2-yl)prop-2-en-1-one

malononitrile

Downstream raw materials:

4-(4-Chloro-phenyl)-6-thiophen-2-yl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile; compound with morpholine

2-bromo-4-(4-chlorophenyl)-6-(2-thienyl)-3-pyridinecarbonitrile

4-(4-chlorophenyl)-6-(thien-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile

4-(4-chlorophenyl)-2-(1-piperidinyl)-6-(2-thienyl)-3-pyridinecarbonitrile