82137-61-9

Upstream product

• 82127-11-5 4-phenyl-6-(thiophen-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 107-14-2 chloroacetonitrile 
• 40219-06-5 benzylidenecyanothioacetamide 
• 88-15-3 2-Acetylthiophene 
• 3988-77-0 2-cinnamoylthiophene 
• 81829-55-2 2-(3-(2-thienyl)-3-oxo-1-phenylpropyl)malononitrile 
• 82127-07-9 2-bromo-6-(2-thienyl)-4-phenyl-3-cyanopyridine 

Downstream Products

• 82127-22-8 3-amino-4-phenyl-6-(2'-thienyl)-thieno[2,3-b]pyridine-2-carbonitrile 
• 539829-83-9 2,4-dithioxo-9-phenyl-1,2,3,4-tetrahydro-7-(2'-thienyl)-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine 
• 539829-92-0 3-amino-2-(4,5-dihydroimidazol-2-yl)-4-phenyl-6-(2'-thienyl)-thieno[2,3-b]pyridine 
• 539829-94-2 3-amino-4-phenyl-6-(2'-thienyl)-2-(1H-tetrazol-2'-yl)-thieno[2,3-b]pyridine 
• 539830-11-0 4-hydrazino-9-phenyl-7-(2'-thienyl)-pyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazine 
• 539830-09-6 4-chloro-9-phenyl-7-(2'-thienyl)-pyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazine 
• 594859-45-7 3-amino-3,4-dihydro-4-imino-9-phenyl-7-(2-thienyl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine 
• 594859-44-6 2-cyano-3-ethoxymethyleneamino-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridine 

Relevant academic research and scientific papers

Some reactions of 2-functionalized 3-amino-4-aryl-6-(2′-thienyl)-thieno[2,3-B]-pyridines: Synthesis of new pyridothienopyrimidines, pyridothienotriazines and related fused tetracyclic systems

4-Aryl-3-cyano-6-(2′-thienyl)-pyridine-2(1H)-thiones (2a-c) were prepared and reacted with chloroacetonitrile or chloroacetamide to furnish 3-amino-4-aryl-6-(2′-thienyl)-thieno[2,3-b]pyridine-2-carbonitriles (4a-c) and 2-carboxamide analogs 6a-c respectiv

Synthesis of some new pyridothienopyrimidines and related [1,2,4]triazolopyridothienopyrimidines

3-Amino-4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxamide (3a) reacted with triethyl orthoformate to give the pyrimidinone derivative 4. Reaction of 4 with phosphorus oxychloride produced the corresponding 4-chloropyrimidine derivative 5 which underwent some nucleophilic displacements upon treatment with thiourea, morpholine or aniline to give the pyridothienopyrimidine derivatives 6, 8 and 9 respectively. Similarly, the reaction of 5 with hydrazine hydrate afforded 4-hydrazino-9-phenyl-7-(2-thienyl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine (10). The condensation of 3-amino-4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridine-2-carbonitrile (3b) with triethyl orthoformate led to the methanimidate derivative 18 which upon treatment with hydrazine hydrate furnished 3-amino-3,4-dihydro-4-imino-9-phenyl-7-(2-thienyl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine (19). The compounds 10 and 19 were used as precursors for synthesizing the isomeric [1,2,4]triazolopyridothienopyrimidines via Dimroth rearrangements.

CYCLIZATION REACTIONS OF NITRILES. 2-ARYL-3-(2-THENOYL)-1,1-DICYANOPROPANES AND PYRIDINE DERIVATIVES BASED ON THEM

In the reaction of 1,1,1-trifluoro-3-(2-thenoyl)acetone with arylidenemalononitriles acid cleavage of the products from Michael addition takes place with the formation of 2-aryl-3-(2-thenoyl)-1,1-dicyanopropanes.They were used for the synthesis of 4-aryl-2-bromo-6-(2-thienyl)-3-cyanopyridines and 4-aryl-6-(2-thienyl)-3-cyano-2(1H)-pyridinethiones and condensed heterocyclic compounds based on them.