82145-97-9Relevant academic research and scientific papers
PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
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Page/Page column 171-172, (2009/11/29)
The invention provides novel inhibitors of hedgehog signaling that are useful as s therapeutic agent for treating malignancies where the compounds have the general formula (I): where A, X, Y R1, R2, R3, R4, m and n are as described herein.
Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors
Paquin, Isabelle,Raeppel, Stephane,Leit, Silvana,Gaudette, Frederic,Zhou, Nancy,Moradei, Oscar,Saavedra, Oscar,Bernstein, Naomy,Raeppel, Franck,Bouchain, Giliane,Frechette, Sylvie,Woo, Soon H.,Vaisburg, Arkadii,Fournel, Marielle,Kalita, Ann,Robert, Marie-France,Lu, Aihua,Trachy-Bourget, Marie-Claude,Yan, Pu Theresa,Liu, Jianhong,Rahil, Jubrail,MacLeod, A. Robert,Besterman, Jeffrey M.,Li, Zuomei,Delorme, Daniel
, p. 1067 - 1071 (2008/09/18)
Inhibition of histone deacetylases (HDAC) is emerging as a new strategy in human cancer therapy. The synthesis and biological evaluation of a variety of 4-(heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides is presented herein. From the different series
α,β-UNSATURATED HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS
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Page/Page column 23, (2008/06/13)
Disclosed are agents that inhibit histone deacetylase. More specifically, the present invention relates to novel hydroxamic acid derivatives or pharmaceutically acceptable salts thereof for anticancer agents or other therapeutic agents based on their histone deacetylase inhibitory activity.
