82157-39-9Relevant academic research and scientific papers
2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety
Smith, Cameron J.,Ali, Amjad,Chen, Liya,Hammond, Milton L.,Anderson, Matt S.,Chen, Ying,Eveland, Suzanne S.,Guo, Qiu,Hyland, Sheryl A.,Milot, Denise P.,Sparrow, Carl P.,Wright, Samuel D.,Sinclair, Peter J.
, p. 346 - 349 (2010)
A series of 2-arylbenzoxazole inhibitors of the cholesterol ester transfer protein (CETP) is described. Structure-activity studies focused on variation of the substitution of the benzoxazole moiety. Substitution at the 5- and 7-positions of the benzoxazol
2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: Optimization via array synthesis
Harikrishnan, Lalgudi S.,Kamau, Muthoni G.,Herpin, Timothy F.,Morton, George C.,Liu, Yalei,Cooper, Christopher B.,Salvati, Mark E.,Qiao, Jennifer X.,Wang, Tammy C.,Adam, Leonard P.,Taylor, David S.,Chen, Alice Ye A.,Yin, Xiaohong,Seethala, Ramakrishna,Peterson, Tara L.,Nirschl, David S.,Miller, Arthur V.,Weigelt, Carolyn A.,Appiah, Kingsley K.,O'Connell, Jonathan C.,Michael Lawrence
, p. 2640 - 2644 (2008/12/21)
2-Arylbenzoxazole 5 was identified as a hit from a fluorescence-based high-throughput screen for CETP inhibitors. The synthesis and SAR investigation employing array synthesis of the A- and B-rings are described.
CETP INHIBITORS
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Page/Page column 63, (2008/06/13)
Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. I
